A: Drug X B: Placebo C: Combination
(N=134) (N=134) (N=132)
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Responders 49 (36.6%) 51 (38.1%) 47 (35.6%)
95% CI (Wald, with correction) (28.0, 45.1) (29.5, 46.7) (27.1, 44.2)
Unstratified Analysis
Difference in Response rate (%) 1.5 -1.0
95% CI (Wald, with correction) (-10.8, 13.8) (-13.3, 11.3)
p-value (Chi-Squared Test) 0.8006 0.8704
Odds Ratio (95% CI) 1.07 (0.65 - 1.75) 0.96 (0.58 - 1.58)
Stratified Analysis
Difference in Response rate (%) 2.8 -1.5
95% CI (CMH, without correction) (-8.2, 13.8) (-13.0, 9.9)
p-value (Cochran-Mantel-Haenszel Test) 0.6397 0.7952
Odds Ratio (95% CI) 1.12 (0.68 - 1.83) 0.99 (0.60 - 1.64)
Experimental use!
WebR is a tool allowing you to run R code in the web browser. Modify the code below and click run to see the results. Alternatively, copy the code and click here to open WebR in a new tab.
A: Drug X B: Placebo C: Combination
Parameter (N=134) (N=134) (N=132)
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BFI All Questions
Responders 57 (42.5%) 65 (48.5%) 50 (37.9%)
95% CI (Wald, with correction) (33.8, 51.3) (39.7, 57.3) (29.2, 46.5)
Unstratified Analysis
Difference in Response rate (%) 6.0 -4.7
95% CI (Wald, with correction) (-6.7, 18.6) (-17.2, 7.9)
p-value (Chi-Squared Test) 0.3264 0.4385
Odds Ratio (95% CI) 1.27 (0.79 - 2.06) 0.82 (0.50 - 1.35)
Stratified Analysis
Difference in Response rate (%) 6.7 -5.1
95% CI (CMH, without correction) (-5.0, 18.4) (-16.8, 6.6)
p-value (Cochran-Mantel-Haenszel Test) 0.2781 0.4056
Odds Ratio (95% CI) 1.30 (0.80 - 2.11) 0.80 (0.49 - 1.32)
Fatigue Interference
Responders 66 (49.3%) 50 (37.3%) 48 (36.4%)
95% CI (Wald, with correction) (40.4, 58.1) (28.8, 45.9) (27.8, 44.9)
Unstratified Analysis
Difference in Response rate (%) -11.9 -12.9
95% CI (Wald, with correction) (-24.5, 0.6) (-25.4, -0.3)
p-value (Chi-Squared Test) 0.0485 0.0337
Odds Ratio (95% CI) 0.61 (0.38 - 1.00) 0.59 (0.36 - 0.96)
Stratified Analysis
Difference in Response rate (%) -12.0 -13.3
95% CI (CMH, without correction) (-23.7, -0.2) (-24.9, -1.6)
p-value (Cochran-Mantel-Haenszel Test) 0.0518 0.0303
Odds Ratio (95% CI) 0.61 (0.37 - 0.99) 0.58 (0.36 - 0.96)
FKSI-19 All Questions
Responders 60 (44.8%) 57 (42.5%) 68 (51.5%)
95% CI (Wald, with correction) (36.0, 53.6) (33.8, 51.3) (42.6, 60.4)
Unstratified Analysis
Difference in Response rate (%) -2.2 6.7
95% CI (Wald, with correction) (-14.9, 10.4) (-6.0, 19.5)
p-value (Chi-Squared Test) 0.7118 0.2714
Odds Ratio (95% CI) 0.91 (0.56 - 1.48) 1.31 (0.81 - 2.12)
Stratified Analysis
Difference in Response rate (%) -2.8 5.6
95% CI (CMH, without correction) (-14.3, 8.8) (-6.2, 17.4)
p-value (Cochran-Mantel-Haenszel Test) 0.6442 0.3683
Odds Ratio (95% CI) 0.90 (0.56 - 1.47) 1.26 (0.77 - 2.04)
Function/Well-Being (GF1,GF3,GF7)
Responders 49 (36.6%) 51 (38.1%) 47 (35.6%)
95% CI (Wald, with correction) (28.0, 45.1) (29.5, 46.7) (27.1, 44.2)
Unstratified Analysis
Difference in Response rate (%) 1.5 -1.0
95% CI (Wald, with correction) (-10.8, 13.8) (-13.3, 11.3)
p-value (Chi-Squared Test) 0.8006 0.8704
Odds Ratio (95% CI) 1.07 (0.65 - 1.75) 0.96 (0.58 - 1.58)
Stratified Analysis
Difference in Response rate (%) 2.8 -1.5
95% CI (CMH, without correction) (-8.2, 13.8) (-13.0, 9.9)
p-value (Cochran-Mantel-Haenszel Test) 0.6397 0.7952
Odds Ratio (95% CI) 1.12 (0.68 - 1.83) 0.99 (0.60 - 1.64)
Treatment Side Effects (GP2,C5,GP5)
Responders 62 (46.3%) 49 (36.6%) 51 (38.6%)
95% CI (Wald, with correction) (37.5, 55.1) (28.0, 45.1) (30.0, 47.3)
Unstratified Analysis
Difference in Response rate (%) -9.7 -7.6
95% CI (Wald, with correction) (-22.2, 2.8) (-20.2, 5.0)
p-value (Chi-Squared Test) 0.1069 0.2080
Odds Ratio (95% CI) 0.67 (0.41 - 1.09) 0.73 (0.45 - 1.19)
Stratified Analysis
Difference in Response rate (%) -9.6 -7.1
95% CI (CMH, without correction) (-21.0, 1.8) (-18.8, 4.6)
p-value (Cochran-Mantel-Haenszel Test) 0.1168 0.2426
Odds Ratio (95% CI) 0.67 (0.41 - 1.10) 0.73 (0.45 - 1.19)
Experimental use!
WebR is a tool allowing you to run R code in the web browser. Modify the code below and click run to see the results. Alternatively, copy the code and click here to open WebR in a new tab.
Code
library(tern)library(dplyr)adsl <- random.cdisc.data::cadsladqs <- random.cdisc.data::cadqs# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.adsl <-df_explicit_na(adsl)adqs <-df_explicit_na(adqs)
shinylive allow you to modify to run shiny application entirely in the web browser. Modify the code below and click re-run the app to see the results. The performance is slighly worse and some of the features (e.g. downloading) might not work at all.