PKCG01

Plot of PK Concentration Over Time by Subject

Code
adpc_a <- adpc %>%
  filter(
    PARAM == "Plasma Drug X",
    ARMCD == "ARM A"
  ) %>%
  mutate(Patient_ID = sub(".*id-", "", USUBJID))

use_title <- "Plot of Plasma Drug X (ug/mL) Concentrations Over Time by\nPatient: PK Evaluable Patients"
use_subtitle <- "Analyte: Plasma Drug X (ug/mL) \nTreatment Group: ARM A"
use_footnote <- "Program: \nOutput:"

result <- g_ipp(
  df = adpc_a,
  xvar = "NFRLT",
  yvar = "AVAL",
  xlab = "Norminal Time from First Dose (hr)",
  ylab = "Concentration (ug/mL)",
  id_var = "Patient_ID",
  add_baseline_hline = FALSE,
  yvar_baseline = "AVAL", #  yvar_baseline cannot be NA or ignore
  title = use_title,
  subtitle = use_subtitle,
  caption = use_footnote,
  plotting_choices = "separate_by_obs"
)
plot <- result[[1]] # only show the first subject
plot

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Code
adpc_a <- adpc %>%
  filter(
    PARAM == "Plasma Drug X",
    ARMCD == "ARM A"
  ) %>%
  mutate(avalog = ifelse(AVAL != 0, AVAL, 0.001)) %>%
  mutate(Patient_ID = sub(".*id-", "", USUBJID))

use_title2 <- "Plot of Plasma Drug X (ug/mL) Concentrations Over Time by\nPatient: PK Evaluable Patients"
use_subtitle2 <- "Analyte: Plasma Drug X (ug/mL) \nTreatment Group: ARM A"
use_footnote2 <- "Program: \nOutput:"

result <- g_ipp(
  df = adpc_a,
  xvar = "NFRLT",
  yvar = "avalog",
  xlab = "Norminal Time from First Dose (hr)",
  ylab = "Concentration (ug/mL)",
  id_var = "Patient_ID",
  add_baseline_hline = FALSE,
  yvar_baseline = "AVAL", #  yvar_baseline cannot be NA or ignore
  title = use_title2,
  subtitle = use_subtitle2,
  caption = use_footnote2,
  plotting_choices = "separate_by_obs"
)
plot <- result[[1]] + ggplot2::scale_y_log10(breaks = c(0.001, 0.01, 0.1, 1, 10), labels = c(0.001, 0.01, 0.1, 1, 10))
plot

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Code
library(tern)
library(dplyr)
library(ggplot2)
library(nestcolor)

adpc <- random.cdisc.data::cadpc

Reproducibility

Timestamp

[1] "2024-11-02 17:56:57 UTC"

Session Info

─ Session info ───────────────────────────────────────────────────────────────
 setting  value
 version  R version 4.4.1 (2024-06-14)
 os       Ubuntu 22.04.5 LTS
 system   x86_64, linux-gnu
 ui       X11
 language (EN)
 collate  en_US.UTF-8
 ctype    en_US.UTF-8
 tz       Etc/UTC
 date     2024-11-02
 pandoc   3.4 @ /usr/bin/ (via rmarkdown)

─ Packages ───────────────────────────────────────────────────────────────────
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 munsell             0.5.1   2024-04-01 [1] CRAN (R 4.4.1)
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 pillar              1.9.0   2023-03-22 [1] CRAN (R 4.4.1)
 pkgconfig           2.0.3   2019-09-22 [1] CRAN (R 4.4.1)
 purrr               1.0.2   2023-08-10 [1] CRAN (R 4.4.1)
 R6                  2.5.1   2021-08-19 [1] CRAN (R 4.4.1)
 random.cdisc.data   0.3.16  2024-11-02 [1] https://insightsengineering.r-universe.dev (R 4.4.1)
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 Rdpack              2.6.1   2024-08-06 [1] CRAN (R 4.4.1)
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 scales              1.3.0   2023-11-28 [1] CRAN (R 4.4.1)
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 stringi             1.8.4   2024-05-06 [1] CRAN (R 4.4.1)
 stringr             1.5.1   2023-11-14 [1] CRAN (R 4.4.1)
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 testthat            3.2.1.1 2024-04-14 [1] CRAN (R 4.4.1)
 tibble              3.2.1   2023-03-20 [1] CRAN (R 4.4.1)
 tidyr               1.3.1   2024-01-24 [1] CRAN (R 4.4.1)
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 withr               3.0.2   2024-10-28 [1] CRAN (R 4.4.1)
 xfun                0.49    2024-10-31 [1] CRAN (R 4.4.1)
 yaml                2.3.10  2024-07-26 [1] CRAN (R 4.4.1)

 [1] /usr/local/lib/R/site-library
 [2] /usr/local/lib/R/library

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