PKPL02

Listing of Drug A Urine PK Parameters

Standard Listing
Data Setup

Preview
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Code

lsting <- as_listing(
  out,
  key_cols = c("TRT01A", "USUBJID", "AVISIT"),
  disp_cols = names(out),
  main_title = paste("Listing of", drug_a, spec, "PK Parameters, PK Population\nProtocol: xxnnnnn"),
  subtitles = paste("Analyte:", drug_a)
)

head(lsting, 20)

Listing of Plasma Drug X Urine PK Parameters, PK Population
Protocol: xxnnnnn
Analyte: Plasma Drug X

———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
Treatment Group        Subject ID             Visit        Renal CL (L/hr)     Renal CL Norm by Dose (L/hr/mg)   Amt Rec from T1 to T2 (mg)   Pct Rec from T1 to T2 (%)
———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
   A: Drug X      AB12345-BRA-1-id-105      SCREENING     0.0538423152160391         0.00441769893771616              2.15210785813109            17.8220657702531     
                                          CYCLE 1 DAY 1   0.0480828455497337         0.00418360874479016              1.77968465488986            13.4821873677008     
                                          CYCLE 1 DAY 2   0.0524191320174391         0.00574562025709617              1.7751362634173             11.7748899262287     
                  AB12345-BRA-1-id-134      SCREENING     0.054828756388858          0.00489378524965625              1.69069405572207            14.6782255303037     
                                          CYCLE 1 DAY 1   0.0463628883891636         0.00281388401660215              1.03364773182262            15.2049132671477     
                                          CYCLE 1 DAY 2   0.0542853013687975         0.00480239019141706              2.07978470495693            16.6499332185177     
                   AB12345-BRA-1-id-42      SCREENING     0.0479776607513692         0.00620670551445586              1.49259200502984            12.4632371401908     
                                          CYCLE 1 DAY 1   0.060136833920038          0.00423749524975822               2.002399829348             16.1228873656652     
                                          CYCLE 1 DAY 2   0.0222050225259149         0.0041513339034891               1.65173021070619             10.129985981426     
                   AB12345-BRA-1-id-93      SCREENING     0.0429283028076499         0.00450841008626937             0.882348047230192            19.8088728992851     
                                          CYCLE 1 DAY 1   0.0343747382858835         0.00495342578722049              1.73500915591676            14.8733500411057     
                                          CYCLE 1 DAY 2   0.0474831008867497         0.00415970555107753              1.30298887256052            14.9616973312841     
                  AB12345-BRA-11-id-217     SCREENING     0.0524432563610182         0.00439177770746837              1.16344390767412             16.584779611686     
                                          CYCLE 1 DAY 1   0.0411628011374518         0.00567801310981526              1.11763922430636            19.3000982041101     
                                          CYCLE 1 DAY 2   0.0672581292323284         0.00400060865194939              1.45655867480937            10.1596117673893     
                  AB12345-BRA-11-id-345     SCREENING     0.044070189259969          0.00561835429596993              1.43739076299198            15.4875095868721     
                                          CYCLE 1 DAY 1   0.0362275034574886         0.0038765297501434                0.96604915921              17.1567306808389     
                                          CYCLE 1 DAY 2   0.0416331541840018         0.00462187415243145              1.27070193721417            19.2547757988484     
                  AB12345-BRA-11-id-397     SCREENING     0.0379747899730378         0.0047876948377162               1.67729762147252            11.6015615292251     
                                          CYCLE 1 DAY 1   0.0430467407701829         0.00463308440642305              1.1695965192594             12.5511219923965

Experimental use!

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Code

library(dplyr)
library(rlistings)

drug_a <- "Plasma Drug X"
spec <- "Urine"

adpp <- random.cdisc.data::cadpp
adpp_x <- adpp %>% filter(
  PPCAT == drug_a,
  PPSPEC == spec
)

out <- adpp_x %>%
  mutate(PARAM = paste0(PARAM, " (", AVALU, ")")) %>%
  select(TRT01A, USUBJID, AVISIT, PARAM, AVAL) %>%
  unique() %>%
  tidyr::pivot_wider(
    id_cols = c(TRT01A, USUBJID, AVISIT),
    names_from = PARAM,
    values_from = AVAL
  )

var_labels(out) <- names(out)
out <- out %>% var_relabel(
  TRT01A = "Treatment Group",
  USUBJID = "Subject ID",
  AVISIT = "Visit"
)

Reproducibility

Timestamp

[1] "2024-11-02 18:24:54 UTC"

Session Info

─ Session info ───────────────────────────────────────────────────────────────
 setting  value
 version  R version 4.4.1 (2024-06-14)
 os       Ubuntu 22.04.5 LTS
 system   x86_64, linux-gnu
 ui       X11
 language (EN)
 collate  en_US.UTF-8
 ctype    en_US.UTF-8
 tz       Etc/UTC
 date     2024-11-02
 pandoc   3.4 @ /usr/bin/ (via rmarkdown)

─ Packages ───────────────────────────────────────────────────────────────────
 package           * version     date (UTC) lib source
 backports           1.5.0       2024-05-23 [1] CRAN (R 4.4.1)
 brio                1.1.5       2024-04-24 [1] CRAN (R 4.4.1)
 checkmate           2.3.2       2024-07-29 [1] CRAN (R 4.4.1)
 cli                 3.6.3       2024-06-21 [1] CRAN (R 4.4.1)
 codetools           0.2-20      2024-03-31 [2] CRAN (R 4.4.1)
 digest              0.6.37      2024-08-19 [1] CRAN (R 4.4.1)
 dplyr             * 1.1.4       2023-11-17 [1] CRAN (R 4.4.1)
 evaluate            1.0.1       2024-10-10 [1] CRAN (R 4.4.1)
 fansi               1.0.6       2023-12-08 [1] CRAN (R 4.4.1)
 fastmap             1.2.0       2024-05-15 [1] CRAN (R 4.4.1)
 formatters        * 0.5.9.9003  2024-11-02 [1] git2r (https://github.com/insightsengineering/formatters.git@84e8c3e)
 generics            0.1.3       2022-07-05 [1] CRAN (R 4.4.1)
 glue                1.8.0       2024-09-30 [1] CRAN (R 4.4.1)
 htmltools           0.5.8.1     2024-04-04 [1] CRAN (R 4.4.1)
 htmlwidgets         1.6.4       2023-12-06 [1] CRAN (R 4.4.1)
 jsonlite            1.8.9       2024-09-20 [1] CRAN (R 4.4.1)
 knitr               1.48        2024-07-07 [1] CRAN (R 4.4.1)
 lifecycle           1.0.4       2023-11-07 [1] CRAN (R 4.4.1)
 magrittr            2.0.3       2022-03-30 [1] CRAN (R 4.4.1)
 pillar              1.9.0       2023-03-22 [1] CRAN (R 4.4.1)
 pkgconfig           2.0.3       2019-09-22 [1] CRAN (R 4.4.1)
 purrr               1.0.2       2023-08-10 [1] CRAN (R 4.4.1)
 R6                  2.5.1       2021-08-19 [1] CRAN (R 4.4.1)
 random.cdisc.data   0.3.16.9001 2024-11-02 [1] git2r (https://github.com/insightsengineering/random.cdisc.data.git@a65bfbe)
 rlang               1.1.4       2024-06-04 [1] CRAN (R 4.4.1)
 rlistings         * 0.2.9.9008  2024-11-02 [1] git2r (https://github.com/insightsengineering/rlistings.git@f6bb1fb)
 rmarkdown           2.28        2024-08-17 [1] CRAN (R 4.4.1)
 sessioninfo         1.2.2       2021-12-06 [1] CRAN (R 4.4.1)
 stringi             1.8.4       2024-05-06 [1] CRAN (R 4.4.1)
 stringr             1.5.1       2023-11-14 [1] CRAN (R 4.4.1)
 testthat            3.2.1.1     2024-04-14 [1] CRAN (R 4.4.1)
 tibble            * 3.2.1       2023-03-20 [1] CRAN (R 4.4.1)
 tidyr               1.3.1       2024-01-24 [1] CRAN (R 4.4.1)
 tidyselect          1.2.1       2024-03-11 [1] CRAN (R 4.4.1)
 utf8                1.2.4       2023-10-22 [1] CRAN (R 4.4.1)
 vctrs               0.6.5       2023-12-01 [1] CRAN (R 4.4.1)
 withr               3.0.1       2024-07-31 [1] CRAN (R 4.4.1)
 xfun                0.48        2024-10-03 [1] CRAN (R 4.4.1)
 yaml                2.3.10      2024-07-26 [1] CRAN (R 4.4.1)

 [1] /usr/local/lib/R/site-library
 [2] /usr/local/lib/R/library

──────────────────────────────────────────────────────────────────────────────

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Reproducibility

Timestamp

Session Info

.lock file

`.lock` file