PKPL01

Listing of Drug A Plasma PK Parameters

Standard Listing
Data Setup

Preview
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Code

lsting <- as_listing(
  out,
  key_cols = c("TRT01A", "USUBJID", "AVISIT"),
  disp_cols = names(out),
  main_title = paste("Listing of", drug_a, spec, "PK Parameters, PK Population\nProtocol: xxnnnnn"),
  subtitles = paste("Analyte:", drug_a)
)

head(lsting, 20)

Listing of Plasma Drug X Plasma PK Parameters, PK Population
Protocol: xxnnnnn
Analyte: Plasma Drug X

————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
Treatment Group        Subject ID             Visit       AUC Infinity Obs (day*ug/mL)   Max Conc (ug/mL)   Total CL Obs (ml/day/kg)
————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
   A: Drug X      AB12345-BRA-1-id-105      SCREENING           145.191684898102         35.5067335878638       5.1567601025515     
                                          CYCLE 1 DAY 1         246.349321001289         31.2264481880236       4.41386730113941    
                                          CYCLE 1 DAY 2         225.443483077171         43.4987268488453       4.81490455551286    
                  AB12345-BRA-1-id-134      SCREENING           157.461703380688         32.1171292884992       6.0374125711965     
                                          CYCLE 1 DAY 1         248.519038520728         21.7795763901966        4.561839813278     
                                          CYCLE 1 DAY 2         230.794839837734         21.0627132276049       6.95200595313275    
                   AB12345-BRA-1-id-42      SCREENING           194.224015921831         20.4565798423567       6.33709739029277    
                                          CYCLE 1 DAY 1         210.528307366678         26.7845825535397       3.50776680376268    
                                          CYCLE 1 DAY 2         167.592869235882         34.8276545020143       4.11969088323673    
                   AB12345-BRA-1-id-93      SCREENING           186.75868084484          27.3983170052516       3.40495133575408    
                                          CYCLE 1 DAY 1         160.406798051843         17.5296885232566       3.8508725098954     
                                          CYCLE 1 DAY 2         252.04512291352          32.4903879259459       6.21586252565961    
                  AB12345-BRA-11-id-217     SCREENING           215.367414313054         20.8879942219526       6.55883385955605    
                                          CYCLE 1 DAY 1         272.094354596647         34.2812274648873       5.04441608634882    
                                          CYCLE 1 DAY 2         174.183265394136          23.04243406023        4.07416508597243    
                  AB12345-BRA-11-id-345     SCREENING           235.746948097021         26.5740342881269       5.52059967823211    
                                          CYCLE 1 DAY 1         228.51025073098          39.7523164840323       6.32996327499752    
                                          CYCLE 1 DAY 2         120.712762389698          24.37143486359        5.02620823564574    
                  AB12345-BRA-11-id-397     SCREENING           165.925716319045         21.8770819414152       6.3713157196375     
                                          CYCLE 1 DAY 1         201.536920713046         36.5841424116449       4.32440907316618

Experimental use!

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Code

library(dplyr)
library(rlistings)

drug_a <- "Plasma Drug X"
spec <- "Plasma"

adpp <- random.cdisc.data::cadpp
adpp_x <- adpp %>% filter(
  PPCAT == drug_a,
  PPSPEC == spec
)

out <- adpp_x %>%
  mutate(PARAM = paste0(PARAM, " (", AVALU, ")")) %>%
  select(TRT01A, USUBJID, AVISIT, PARAM, AVAL) %>%
  tidyr::pivot_wider(
    id_cols = c(TRT01A, USUBJID, AVISIT),
    names_from = PARAM,
    values_from = AVAL
  )

var_labels(out) <- names(out)
out <- out %>% var_relabel(
  TRT01A = "Treatment Group",
  USUBJID = "Subject ID",
  AVISIT = "Visit"
)

Reproducibility

Timestamp

[1] "2024-11-02 18:24:46 UTC"

Session Info

─ Session info ───────────────────────────────────────────────────────────────
 setting  value
 version  R version 4.4.1 (2024-06-14)
 os       Ubuntu 22.04.5 LTS
 system   x86_64, linux-gnu
 ui       X11
 language (EN)
 collate  en_US.UTF-8
 ctype    en_US.UTF-8
 tz       Etc/UTC
 date     2024-11-02
 pandoc   3.4 @ /usr/bin/ (via rmarkdown)

─ Packages ───────────────────────────────────────────────────────────────────
 package           * version     date (UTC) lib source
 backports           1.5.0       2024-05-23 [1] CRAN (R 4.4.1)
 brio                1.1.5       2024-04-24 [1] CRAN (R 4.4.1)
 checkmate           2.3.2       2024-07-29 [1] CRAN (R 4.4.1)
 cli                 3.6.3       2024-06-21 [1] CRAN (R 4.4.1)
 codetools           0.2-20      2024-03-31 [2] CRAN (R 4.4.1)
 digest              0.6.37      2024-08-19 [1] CRAN (R 4.4.1)
 dplyr             * 1.1.4       2023-11-17 [1] CRAN (R 4.4.1)
 evaluate            1.0.1       2024-10-10 [1] CRAN (R 4.4.1)
 fansi               1.0.6       2023-12-08 [1] CRAN (R 4.4.1)
 fastmap             1.2.0       2024-05-15 [1] CRAN (R 4.4.1)
 formatters        * 0.5.9.9003  2024-11-02 [1] git2r (https://github.com/insightsengineering/formatters.git@84e8c3e)
 generics            0.1.3       2022-07-05 [1] CRAN (R 4.4.1)
 glue                1.8.0       2024-09-30 [1] CRAN (R 4.4.1)
 htmltools           0.5.8.1     2024-04-04 [1] CRAN (R 4.4.1)
 htmlwidgets         1.6.4       2023-12-06 [1] CRAN (R 4.4.1)
 jsonlite            1.8.9       2024-09-20 [1] CRAN (R 4.4.1)
 knitr               1.48        2024-07-07 [1] CRAN (R 4.4.1)
 lifecycle           1.0.4       2023-11-07 [1] CRAN (R 4.4.1)
 magrittr            2.0.3       2022-03-30 [1] CRAN (R 4.4.1)
 pillar              1.9.0       2023-03-22 [1] CRAN (R 4.4.1)
 pkgconfig           2.0.3       2019-09-22 [1] CRAN (R 4.4.1)
 purrr               1.0.2       2023-08-10 [1] CRAN (R 4.4.1)
 R6                  2.5.1       2021-08-19 [1] CRAN (R 4.4.1)
 random.cdisc.data   0.3.16.9001 2024-11-02 [1] git2r (https://github.com/insightsengineering/random.cdisc.data.git@a65bfbe)
 rlang               1.1.4       2024-06-04 [1] CRAN (R 4.4.1)
 rlistings         * 0.2.9.9008  2024-11-02 [1] git2r (https://github.com/insightsengineering/rlistings.git@f6bb1fb)
 rmarkdown           2.28        2024-08-17 [1] CRAN (R 4.4.1)
 sessioninfo         1.2.2       2021-12-06 [1] CRAN (R 4.4.1)
 stringi             1.8.4       2024-05-06 [1] CRAN (R 4.4.1)
 stringr             1.5.1       2023-11-14 [1] CRAN (R 4.4.1)
 testthat            3.2.1.1     2024-04-14 [1] CRAN (R 4.4.1)
 tibble            * 3.2.1       2023-03-20 [1] CRAN (R 4.4.1)
 tidyr               1.3.1       2024-01-24 [1] CRAN (R 4.4.1)
 tidyselect          1.2.1       2024-03-11 [1] CRAN (R 4.4.1)
 utf8                1.2.4       2023-10-22 [1] CRAN (R 4.4.1)
 vctrs               0.6.5       2023-12-01 [1] CRAN (R 4.4.1)
 withr               3.0.1       2024-07-31 [1] CRAN (R 4.4.1)
 xfun                0.48        2024-10-03 [1] CRAN (R 4.4.1)
 yaml                2.3.10      2024-07-26 [1] CRAN (R 4.4.1)

 [1] /usr/local/lib/R/site-library
 [2] /usr/local/lib/R/library

──────────────────────────────────────────────────────────────────────────────

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Reproducibility

Timestamp

Session Info

.lock file

`.lock` file