Changelog
Source:NEWS.md
tern 0.9.0.9006
New Features
 Added
imputation_rule
function to apply imputation rule to data.  Added new format function
format_sigfig
to allow for numeric value formatting by a specified number of significant figures.  Added vectors containing default statistic formats and labels as
tern_default_formats
andtern_default_labels
, respectively.  Added function
get_stats
to return methods from given statistical method groups.  Added function
get_formats_from_stats
to return formats andget_labels_from_stats
to return labels for a given set of statistics.  Added
"auto"
option for.formats
. It usesformat_auto
to determine automatically the number of digits.  Added
title
argument toh_grob_tbl_at_risk
andannot_at_risk_title
argument tog_km
andh_km_layout
which allows user to add “Patients at Risk” title to KaplanMeier at risk annotation table.
Enhancements
 Refactored
tabulate_rsp_subgroups
to pass sanitation checks by preventing creation of degenerate subtables.  Updated
analyze_vars_in_cols
to use caching, allow implementation of imputation rule via theimp_rule
argument, and allow user to specify cell alignment via the.aligns
argument.  Updated
add_rowcounts
to allow addition of row counts fromalt_counts_df
using thealt_counts
argument.  Added
gp
argument tog_forest
to control graphical parameters such as font size.
Miscellaneous
 Grouped functions relating to valid method names and their default formats and labels into new source file
utils_defaults_handling.R
.  Started deprecation of
summary_custom()
anda_summary()
as aS3
method.  Renamed statistical method for
pvalue
in the discrete case topval_counts
.  Removed
a_summary_internal()
in favor of only one maina_summary()
.
tern 0.9.0
CRAN release: 20230901
New Features
 Added
stat_propdiff_ci
function to calculate proportion/risk difference and CI.  Added risk difference column functionality via the
riskdiff
argument to functionscount_occurrences
,count_occurrences_by_grade
,count_patients_with_event
,count_patients_with_flags
,analyze_num_patients
, andsummarize_num_patients
.
Enhancements
 Refactored the function
a_summary
to no longer use the helper functioncreate_afun_summary
.  Refactored functions
summarize_vars
andcompare_vars
to use the refactoreda_summary
function.  Created new internal helper functions
ungroup_stats
to ungroup statistics calculated for factor variables, anda_summary_internal
to perform calculations fora_summary
.
Bug Fixes
 Fixed bug in
s_count_occurrences_by_grade
so that “missing” grade always appears as the final level.  Fixed bug in
analyze_vars_in_cols
when categorical data was used.  Fixed bug in
s_count_occurrences_by_grade
so that levels are not relabeled when reordering to account for “missing” grades.
tern 0.8.5
Enhancements
 Added
ylim
argument tog_km
to allow the user to set custom limits for the yaxis.  Added assertion to
g_km
which checks whether there is one arm present in the data whenannot_coxph
is true.  Added
flag_labels
argument tos_count_patients_with_flags
to enable more label handling options incount_patients_by_flags
.  Added the
nested
argument toanalyze
wrapper functionscount_abnormal
,count_abnormal_by_baseline
,count_abnormal_by_marked
,count_abnormal_by_worst_grade
,count_abnormal_lab_worsen_by_baseline
,count_cumulative
,count_missed_doses
,count_occurrences
,count_occurrences_by_grade
,count_patients_with_event
,count_patients_with_flags
,count_values
,estimate_multinomial_response
,estimate_proportion
,estimate_incidence_rate
,estimate_odds_ratio
,estimate_proportion_diff
,test_proportion_diff
,summarize_ancova
,summarize_change
,summarize_glm_count
,analyze_num_patients
,coxph_pairwise
,surv_time
, andsurv_timepoint
.
tern 0.8.4
CRAN release: 20230627
Enhancements
 Added method for
character
class toh_coxreg_inter_effect
enablingcharacter
covariates insummarize_coxreg
.
Miscellaneous
 Began deprecation of
time_unit_input
andtime_unit_output
arguments and replaced them with theinput_time_unit
andnum_pt_year
, respectively, incontrol_incidence_rate
.  Removed deprecated
pairwise
function.  Deprecated
a_compare
and replaced it witha_summary
with argumentcompare = TRUE
.  Deprecated helper functions
create_afun_summary
andcreate_afun_compare
which are no longer used bya_summary
anda_compare
respectively.
tern 0.8.3
CRAN release: 20230619
Enhancements
 Added explicit zero counts to
g_km
plot “at risk” annotation tables.  Added a flag for total level split in
analyze_patients_exposure_in_cols
.  Implemented
.indent_mods
argument in functionsh_tab_one_biomarker
,h_tab_rsp_one_biomarker
,h_tab_surv_one_biomarker
,summarize_logistic
,logistic_summary_by_flag
,tabulate_rsp_biomarkers
,a_coxreg
,summarize_coxreg
,tabulate_survival_biomarkers
,surv_time
,surv_timepoint
, andcfun_by_flag
.  Updated
summarize_coxreg
to print covariates in data rows for univariate Cox regression with no interactions and content rows otherwise.  Removed “baseline status” text from
d_count_abnormal_by_baseline
labels.  Improved default sizing of annotation tables in
g_km
and added dynamic scaling of thesurv_med
andcoxph
annotation tables, with customization via thewidth_annots
argument.
Bug Fixes
 Fixed bug in
split_text_grob
preventing titles and footnotes from being properly formatted and printed bydecorate_grob
.  Fixed bug in
g_lineplot
preventing the addition of lines to the plot when midpoint statistic calculations result inNA
value(s).  Fixed
tern:::tidy.glm
formals to respectbroom:::tidy.default
formals.
Miscellaneous
 Updated
README
to include installation instructions for CRAN.  Remove examples for unexported functions.
 Export functions
has_count_in_cols
,has_counts_difference
,combine_counts
,h_tab_rsp_one_biomarker
,arrange_grobs
,a_count_patients_sum_exposure
,a_coxreg
,groups_list_to_df
,forest_viewport
.  Updated
README
to include installation instructions for CRAN.  Began deprecation of
indent_mod
argument and replaced it with the.indent_mods
argument insummarize_num_patients
andanalyze_num_patients
.
tern 0.8.2
Breaking Changes
 Refactored
s_coxreg
andsummarize_coxreg
to work with new analysis functiona_coxreg
.
Enhancements
 Added
section_div
andna_level
arguments tosummarize_vars
.  Added
median_range
as a numeric variable statistic option forsummarize_vars
.  Corrected ordering of factor levels by
d_onco_rsp_label
.  Added new “Analyze Functions”, “Summarize Functions”, and “Analyze Functions on Columns” overview pages.
 Consolidated all KM plot documentation within the
g_km
function.  Added
a_count_patients_sum_exposure
forsummarize_patients_exposure_in_cols
and new analyze functionanalyze_patients_exposure_in_cols
.  Added more informative error when the user selects an invalid method for unstratified analyses in
s_proportion_diff
.  Updated
s_summary
ands_compare
to allowNA
values in input variables. For factor variables withNA
s, ifna.rm = FALSE
an explicitNA
level will be automatically added.na.rm = TRUE
will also consider"<Missing>"
values and exclude them.  Updated purpose of
na_level
parameter ins_summary
ands_compare
to align with othertern
functions. Instead of being a string to consider asNA
when settingna.rm = TRUE
, it now defines a string to print in place ofNA
values in the output table.
Bug Fixes
 Fixed missing label for
TRTEDTM
intern
datasets.  Fixed improper implementation of
na_level
argument insummarize_vars
preventing it from having an effect.
Miscellaneous
 Implemented the
lubridate
package for date variables intern
datasets.  Organized
.gitignore
and.Rbuildignore
files.  Removed deprecated
footnotes
functions and all related files.  Started deprecation cycle for
pairwise
function.  Moved
count_patients_with_flags
functions fromcount_patients_with_event.R
tocount_patients_with_flags.R
.
tern 0.8.0
Enhancements
 Added
summarize_glm_count
function to analyze count data using a linear model.  Added legend to
g_step
.  Added formatting functions
format_fraction_fixed_dp
andformat_count_fraction_fixed_dp
with fixed single decimal place in percentages.  Added
na_level
andlabelstr
arguments tosummarize_vars_in_cols
.  Added
analyze_num_patients
to include summary at the beginning that does not repeat when paginating.  Added
h_row_first_values
function as a more general helper function to retrieve first values from specific rows.  Added option to remove
"(n)"
suffix fromunique_count
labels fors_num_patients
.  Added options to
g_km
to annotate with statistics (annot_stats
) and add corresponding vertical lines (annot_stats_lines
).
Bug Fixes
 Fixed bug causing incorrect ordering of numeric grade levels when missing grades are present in
s_count_occurrences_by_grade
.  Refactored
summarize_vars_in_cols
to work with pagination machinery.  Fixed bug to allow passing of
conf_level
argument toemmeans::contrast()
ins_ancova
.  Fixed bugs in
rtables_access.R
caused by not checking for specific combinations (also the standard values that were never used) of column indices and names.  Fixed single applicable record bug in
count_abnormal_by_grade
.  Fixed bug in
add_rowcounts
that caused all row count row values to count as zero.  Fixed bug in
h_col_indices
causing an error when pruning with combination columns.  Fixed bug in
test_proportion_diff
missing argument forvar_labels
.
Documentation and Tests
 Added more tests to increase code coverage.
 Created separate documentation files for functions in different sections of
pkgdown
reference.  Created separate
.R
files for logistic regression and cox regression helper functions.  Fixed table tests using
analyze_num_patients
to generate an initial summary so there is no repetition when paginating.  Updated tests to use
testthat
3rd edition and replaced applicable tests with snapshot testing.  Updated
summarize_ancova
examples to useiris
dataset instead ofscda
data.  Created vignette which saves cached synthetic
CDISC
dataset files to thedata/
folder and generated cached synthetic datasets.  Updated all examples/tests to use datasets from the
data/
folder instead ofscda
datasets.  Removed all template tests from
tern
. These tests are in internal reposcda.test
.
Miscellaneous
 Renamed
summarize_vars_in_cols
toanalyze_vars_in_cols
to reflect the appropriateanalyze
logic.  Removed redundant
summary_in_cols
helper functions.  Exported function
format_xx
.  Replaced deprecated
ggplot2
functions/arguments to fix warnings.  Replaced deprecated function
forcats::fct_explicit_na
withforcats::fct_na_value_to_level
.  Removed deprecated
wrap_text
function and related files.  Started deprecation cycle for
footnotes
functions.
tern 0.7.10
New Features
 Added stratified
Newcombe
and stratified Wilson statistics toestimate_proportion
andestimate_proportion_diff
with relative tests.  Added
stat_mean_pval
, a new summary statistic to calculate the pvalue of the mean.  Added statistic
mean_se
(mean with standard error) forsummarize_variables
and related functions.  Introduced again
Rdpack
for references.
Enhancements
 Redesign of data handling in tests by removing repetitive data loads and library calls.
 Added
DescTools::BinomDiffCI
function withintern
.  Added new parameter to
summarize_logistic
to specify which pivoted value to use during analysis.  Updated
s_coxph_pairwise
to generate logrank pvalue using original logrank test instead of Cox ProportionalHazards Model.  Implemented
nestcolor
in all examples by adaptingg_km
,g_ipp
,g_waterfall
,g_step
,g_lineplot
, andg_forest
.  Added parameters
interaction_y
andinteraction_item
inANCOVA
to make the interaction calculations available.  Added new parameter
footnotes
to add footnotes tog_km
.
Migration from assertthat
to checkmate
 Implemented
checkmate::assert_vector
,checkmate::assert_set_equal
, andcheckmate::assert_int
to check vector type, length, and values.  Replaced with standard assertions from
checkmate
the following functions:all_elements_in_ref
,is_df_with_nlevels_factor
,is_df_with_no_na_level
,is_proportion_vector
,is_quantiles_vector
,is_character_or_factor
,is_nonnegative_count
,is_valid_character
,assert_character_or_factor
,assert_equal_length
andhas_tabletree_colnames
.  Modified
is_proportion
,is_equal_length
,is_df_with_no_na_level
,is_df_with_nlevels_factor
,is_variables
,is_df_with_variables
,is_df_with_factors
,is_valid_factor
to use assertion logic.  Added more verbose warnings from
as_factor_keep_attributes
.  Made
assert_df_with_factors
andassert_proportion_value
internal functions.  Renamed
assertthat.R
andtestassertthat.R
toutils_checkmate.R
andtestutils_checkmate.R
.
Documentation and NAMESPACE Polishing
 Added stable badges for:

count_abnormal_by_marked
(reference toabnormal_by_marked
),count_abnormal_lab_worsen_by_baseline
andh_adlb_worsen
(reference toabnormal_by_worst_grade_worsen_from_baseline
),count_abnormal_by_worst_grade
(reference toabnormal_by_worst_grade
),to_string_matrix
,tidy.summary.coxph
,tidy.step
,surv_timepoint
, (reference tosurvival_timepoint
),surv_time
(reference tosurvival_time
),coxph_pairwise
(reference tosurvival_coxph_pairwise
),extract_survival_subgroups
andtabulate_survival_subgroups
(reference tosurvival_duration_subgroups
),extract_survival_biomarkers
andtabulate_survival_biomarkers
(reference tosurvival_biomarkers_subgroups
),control_summarize_vars
,s_summary
anda_summary
(reference tosummarize_variables
) and kept the S3 method tree. 
summarize_patients_exposure_in_cols
,summarize_num_patients
withs_num_patients
,s_num_patients_content
,summarize_num_patients
. 
count_cumulative
,count_missed_doses
,count_patients_events_in_cols
,summarize_colvars
,summarize_change
,summarize_ancova
,as.rtable
,color_palette
,add_footnotes
.  (statistical function controls)
control_coxreg
,control_coxph
,control_incidence_rate
,control_lineplot_vars
,control_surv_time
,control_surv_timepoint
,control_logisitic
,control_step
. 
stat_mean_ci
,stat_median_ci
,split_cols_by_groups
,explicit_na
,sas_na
,extract_rsp_subgroups
,tabulate_rsp_subgroups
,extract_rsp_biomarkers
,tabulate_rsp_biomarkers
,keep_rows
,keep_content_rows
,has_count_in_any_col
,has_fraction_in_cols
,has_fraction_in_any_col
,has_fractions_difference
,test_proportion_diff
,pairwise
,logistic_regression
,estimate_incidence_rate
,control_incidence_rate
(reference toincidence_rate
),cut_quantile_bins
,estimate_multinomial_rsp
,decorate_grob_set
,extreme_format
,fit_rsp_step
,fit_survival_step
,footnotes
,footnotesset
,format_count_fraction
,format_fraction_threshold
,formatting_functions
,format_fraction
,combination_function
(S4 method),compare_variables
(S3 method),kaplan_meier
.

 Internal keywords added, export removed,
_pkgdown.yml
updated, andtern:::
added for tests/examples/vignettes where present for the following functions: (chain functions, reference to
abnormal_by_marked
)s_count_abnormal_by_marked
,a_count_abnormal_by_marked
.  (chain functions, reference to
abnormal_by_worst_grade_worsen_from_baseline
)a_count_abnormal_lab_worsen_by_baseline
,s_count_abnormal_lab_worsen_by_baseline
.  (chain functions, reference to
abnormal_by_worst_grade
)s_count_abnormal_by_worst_grade
,a_count_abnormal_by_worst_grade
.  (chain functions, reference to
survival_timepoint
)s_surv_timepoint
,s_surv_timepoint_diff
,a_surv_timepoint
,a_surv_timepoint_diff
.  (chain functions, reference to
survival_time
)s_surv_time
,a_surv_time
.  (chain functions, reference to
survival_coxph_pairwise
)s_coxph_pairwise
,a_coxph_pairwise
.  (chain functions, reference to
survival_duration_subgroups
)a_survival_subgroups
.  (chain functions, reference to
count_cumulative
)s_count_cumulative
,a_count_cumulative
.  (chain functions, reference to
count_missed_doses
)s_count_nonmissing
,s_count_missed_doses
,a_count_missed_doses
.  (chain functions, reference to
count_patients_events_in_cols
)s_count_patients_and_multiple_events
,summarize_patients_events_in_cols
.  (chain functions, reference to
incidence_rate
)s_incidence_rate
,a_incidence_rate
.  (cox regression helper)
cox_regression_inter
,decorate_grob_factory
,draw_grob
,estimate_coef
. 
summary_labels
,summary_formats
,s_count_patients_sum_exposure
,a_change_from_baseline
s_change_from_baseline
,a_ancova
,s_ancova
,arrange_grobs
,as_factor_keep_attributes
,combine_levels
,split_text_grob
,groups_list_to_df
,s_cox_multivariate
,is_leaf_table
,a_response_subgroups
,range_noinf
,has_count_in_cols
,has_counts_difference
,prop_chisq
,prop_cmh
,prop_schouten
,prop_fisher
,s_test_proportion_diff
,a_test_proportion_diff
,fct_discard
,fct_explicit_na_if
.
 (chain functions, reference to
Bug Fixes
 Fixed retrieval method of
stats::ancova
output due to version inconsistency.  Fixed tests to respect the new standard print for
NA
coming fromrtables
.  Fixed error in tests coming from changes in
formatters::var_labels
.  Fixed
prop_diff
functions to respect success responses (TRUE
values).  Fixed error coming from comparing factors vector to characters vector.
 Fixed empty vector exception for
cut_quantile_bins
.  Fixed exception error when empty strings are present in pivoted columns (
rtables
split functions)  Fixed bug in
s_ancova
causing an error when the first level of the arm factor is not the control arm.  Fixed bug in
s_abnormal_by_worst_grade
when there is onePARAM
level.  Fixed bug in
prop_diff_wald
when selecting all responders, updated tests accordingly.  Fixed bug in
h_ancova
that caused an error when deselecting all covariates.
Miscellaneous
 Added deprecated badge to
g_mmrm
.  Removed internal function calls in examples (
tern:::
) and addeddontrun
to internal function examples.  Removed warnings and messages to console occurring in examples and tests.
 Deprecated functions
color_palette
andh_set_nest_theme
in favor ofnestcolor::color_palette
andnestcolor::theme_nest
, respectively.  Removed deprecated functions:
color_palette
,color_palette_core
,h_set_nest_theme
,s_cox_univariate
.  Removed deprecated
mmrm
functions:fit_mmrm
,g_mmrm_diagnostic
,g_mmrm_lsmeans
,as.rtable.mmrm
,h_mmrm_fixed
,h_mmrm_cov
,h_mmrm_diagnostic
,tidy.mmrm
,s_mmrm_lsmeans
,s_mmrm_lsmeans_single
,summarize_lsmeans
.  Renamed functions
arm
tostudy_arm
andextract
toextract_by_name
.  Renamed
rtables.R
toutils_rtables.R
.  Extracted
cox_regression_inter
into a separate file fromcox_regression
.  Renamed
estimate_incidence_rate.R
toincidence_rate.R
to match the documentation grouping name.  Extracted
control_incidence_rate
into a separate file because it produces a separate documentation file.  Added
@md
and removed@order
fromincidence_rate.R
. Modified examples accordingly.  Removed hyperlink from
prop_schouten
function documentation.  Exported
draw_grob
function.
tern 0.7.8
Documentation and NAMESPACE polishing
 Adopting the standard of badges for
@description
instead of every@descriptionIn
function. Corrected accordinglysummarize_variables_in_cols
 Added stable badge for
g_lineplot
,g_step
,g_waterfall
,cox_regression
,score_occurrences
,add_rowcounts
,odds_ratio
,count_occurrences
,count_occurrences_by_grade
,explicit_na
,df_explicit_na
,count_patients_with_event
,decorate_grob
,combine_groups
,append_varlabels
,univariate
,stack_grobs
,count_abnormal
(reference toabnormal
),count_abnormal_by_baseline
(reference toabnormal_by_baseline
).  Internal keywords added, export removed,
_pkgdown.yml
polished andtern:::
for tests, examples, and vignettes when present for the following functions: (helper functions)
h_format_row
,h_map_for_count_abnormal
 (utils functions)
make_names
,month2day
,day2month
empty_vector_if_na
,aesi_label
,n_available
,format_xx
,arm
. 
count_values_funs
,prop_difference
,combine_counts
.  (chain functions)
s_count_abnormal
,a_count_abnormal
.  (chain functions)
s_count_abnormal_by_baseline
,a_count_abnormal_by_baseline
,d_count_abnormal_by_baseline
.
 (helper functions)
 Deprecated
s_cox_univariate
function has now deprecated badge.
Enhancements
 Enhanced
g_lineplot
with table to automatically scale the table height and return aggplot
object.  Enhanced
g_ipp
with caption argument and adjust the position.  Enhanced
prop_diff
,tern
function and related functions to be able to apply a continuity correction in theNewcombe
method.  Enhanced
summarize_numeric_in_columns
andsummarize_variables
to allow factor/character summary and to be able to summarize the number ofBLQs
inAVALC
fromADPC
dataset.  Updated order of summarize variables stats in manual for order consistency.
 Added a
sum
option tosummarize_variables
.  Use consistent color palette for plotting (
stream
by default).  Enhanced
h_pkparam_sort
function with argumentkey_var
to allow data with different column names.
Miscellaneous
 Updated
testtable_aet02.R
variant 12.  Changed the
scda
data version to ‘20220228’.  Added a template to the
pkgdown
site.  Removed package dependencies of
grDevices
,stringr
, andviridisLite
.  Renaming
summarize_numeric_in_columns
tosummarize_variables_in_columns
.  Renaming
summarize_vars_numeric_in_cols
tosummarize_vars_in_cols
.  Fixed a bug where points on the
g_lineplot
plot were not connected when missing values.  Updated the package authors.
tern 0.7.7
New features
 Added
h_pkparam_sort
to orderPK PARAM
value based on the order of the dataset generated byd_pkparam()
.  Added
d_pkparam
to generate PK parameter map for sorting.
tern 0.7.6
New features
 Added
h_map_for_count_abnormal
to create the map used intrim_levels_to_map
split function by calling this helper function. It supports two methods: one with all observed mapping, one with at least low limit above zero and at least one non missing high limit.  Added
s_summary_numeric_in_cols
andsummarize_vars_numeric_in_cols
functions to generate summary statistics in columns, mainly used for PK datasets.  Added five statistics to
s_summary.numeric
to use ins_summary_numeric_in_cols
.
Enhancements
 Enhanced functions
tabulate_survival_subgroups
andtabulate_rsp_subgroups
(Survival Duration and Best Response analyses) to calculateN
s based on the records considered to create the model.  Enhanced the function
estimate_proportion
and related functions to be able to apply a continuity correction in the Wilson method.  Refactored
count_abnormal_by_marked
and related statistics and formatting functions to use a more efficient layout with.spl_context
argument used for determining denominators and withtrim_levels_to_map
split function undersplit_rows_by
to show the desired levels in the table. This is a breaking change.  Refactored
count_abnormal_by_worst_grade
and related statistics and formatting functions to use a more efficient layout with.spl_context
argument used for determining denominators and withtrim_levels_to_map
split function undersplit_rows_by
to show the desired levels in the table. This is a breaking change.  Refactored
count_abnormal
function and related statistics and formatting functions to use a more efficient layout withtrim_levels_to_map
split function undersplit_rows_by
to show the desired levels in the table. Also updatedabnormal
argument to be able to consider more than one level for each direction. This is a breaking change.  Enhanced the function
estimate_incidence_rate
and related functions to consider the week as time unit for data input.
tern 0.7.5
New features
 Added functions to estimate continuous biomarker effects across subgroups for survival and binary response endpoints, used to produce corresponding forest plots, see
survival_biomarkers_subgroups
andresponse_biomarkers_subgroups
.  Added
g_lineplot
plot function, including newh_format_row
helper function andcontrol_lineplot_vars
function. Removedg_summary_by
.  Added new safety helper function
h_stack_by_baskets
to stack events inSMQ
and/orCQ
basket flag inADAE
data set.
Enhancements
 Added a couple of new statistics to
s_summary.numeric
. Addednames
attribute to each element of the final list returned by thes_summary.numeric
function. Addedsummary_formats
andsummary_labels
helper functions.  Added option to also convert logical variables to factor variables in
df_explicit_na
.  Refactored
h_append_grade_groups
to improve its flexibility, robustness and clearness, and to make sure the result is ordering according to the order ofgrade_groups
. Also, addedremove_single
argument which controls whether the elements of oneelement grade groups are in the output or removed.  Added
var_labels
andshow_labels
arguments tocount_occurrences
andcount_patients_with_flags
to allow for creation of a title row.  Added
na_level
argument tocount_abnormal_by_baseline
.  Updated
h_append_grade_groups
to no longer fillin empty grade groups with zeros.
Bug Fixes
 Fixed
prop_diff_cmh
to handle edge case of no FALSE (or TRUE) responses.  Enhanced
g_mmrm_diagnostic
to improve error handling when data is not amenable to the Locally Weighted Scatterplot Smoothing.  Fixes in
g_km
: Plot can now display any combination of the annotation tables for number of patients at risk, median survival time, and
CoxPH
summary.  Function will return a warning instead of an error if the
arm
variable includes a single level andannot_coxph = TRUE
.  Lines in the plot now start at time 0 and probability 1.
 Category labels can include the equals sign.
 Plot can now display any combination of the annotation tables for number of patients at risk, median survival time, and
Miscellaneous
 Fixed
day2month
andmonth2day
to work with NA data.  Added parameters for
stat_mean_ci
andstat_median_ci
so that they may return different outputs.  Added functionality in
h_row_counts
to handle analysis rows withNULL
cells.  Updated
LICENCE
andREADME
with new package references.  Added
error_on_lint: TRUE
to.lintr
.
tern 0.7.4
New features
 Added new safety layout functions:

count_abnormal_by_marked
tabulates marked laboratory abnormalities. 
summarize_patients_exposure_in_cols
tabulates patient counts and sum of exposure across all patients.

Enhancements
 Enhanced
mmrm
related functions for fitting models withoutarm
variable.  Updated
cox_regression
to work without covariates. Also in case of interaction model summary, pvalues for main effect coefficients are no longer displayed.  Descriptive statistics returned by
summarize_vars
now include quantiles.summarize_vars
now accepts the control functioncontrol_summarize_vars
to specify details about confidence level for mean and median and quantile details. Thecontrol
argument replacesconf_level
.  Added
var_labels
andshow_labels
arguments tocount_occurrences_by_grade
.  Changed
indent
argument inappend_varlabels
to accept nonnegative integer to represent the indent space defined by user. Previous calls with Booleanindent
will do an integer conversion and produce a warning.
Bug Fixes
 Corrected
tabulate_survival_subgroups
and related survival forest plot functions to use total number of events, instead of observations, as default for scaling the symbol sizes in the plot. (The user might still use total number of observations manually if they wish to do so.)  Helper function
h_adsl_adlb_merge_using_worst_flag
will now imputeBTOXGR
for missing visits.
tern 0.7.3
New Features
 Added Subgroup Treatment Effect Pattern (STEP) model fitting functions
fit_rsp_step
andfit_survival_step
, the corresponding tidy methodtidy.step
as well as the graph functiong_step
.  Added new layout function
compare_vars
which compares variables of different types between columns and produces a pvalue for the comparison to the reference column. Function built on top of thesummarize_vars
functionality.  Added utility functions:

cut_quantile_bins
cuts a numeric vector into quantile bins. 
fct_collapse_only
collapses levels of a factor and keeps those in the order provided. 
fct_explicit_na_if
inserts explicit missings in a factor based on a condition. 
range_noinf
is a kind of a wrapper function ofbase::range
. It returnsc(NA, NA)
instead ofc(Inf, Inf)
for zerolength data.

Enhancements
 Cox regression via
fit_coxreg_univar
andfit_coxreg_multivar
is now also possible without treatment arm. In the univariate case this means that it fits separate univariate models for the provided covariates and tabulation of corresponding effect estimates can later occur.  Added
fraction
in result returned bys_count_occurrences
. It contains a list of numerators and denominators with one element per occurrence.  Updated
sum_num_patients
andcount_occurrences
for the resultunique
andcount_fraction
to return (0, 0) when input is empty.  Added a new argument
groups_lists
toextract_survival_subgroups
,extract_rsp_subgroups
and associated helper functions which allows to group factor levels of subgroup variables into manually defined groups, enhancing the flexibility of the resulting forest graphs.  Forest graph function
g_forest
now extracts default arguments from attributes of the input table produced bytabulate_rsp_subgroups
andtabulate_survival_subgroups
so that the user does not have to do this manually anymore.  In
g_km
: Remove arm variable name from arm labels in plot legend and annotation tables.
 Show symbol used to mark censored cases and match order of arm variable factor levels in the legend.
 Display hazard ratio and its confidence interval to two decimal places.
 Updated default position of hazard ratio table to stay on the left bottom corner but above xaxis.
 Use arm value as strata name in when treatment arm variable has a single level.
 Updated
s_surv_time
function to use a newly created functionrange_noinf
instead ofbase::range
.  New argument
no_fillin_visits
added toh_adsl_adlb_merge_using_worst_flag
to specify excluded visits from the postbaseline worst toxicity grade output. Improvedh_adsl_adlb_merge_using_worst_flag
to include variables shared betweenadsl
andadlb
, along withPARAM
,PARAMCD
,ATOXGR
,BTOXGR
and optionallyAVISIT
,AVISITN
whenby_visit = TRUE
. Prior output containedUSUBJID
,ARMCD
,PARAMCD
,ATOXGR
, andBTOXGR
.
Bug Fixes
 Fix bug in
s_surv_timepoint
for cases when there are zero patients at risk.  Modified
stat_median_ci
function so that when passing empty var with empty name, norow names contain missing values
error would show.
Miscellaneous
 Deprecated
s_cox_univariate
function, usefit_coxreg_univar
function instead.  Updated default formats of
hr
andhr_ci
ina_coxph_pairwise
and median ins_surv_time
to align with STREAM.  Updated the preprocessing code in the files
testtable_ttet01.R
andtesttable_dort01.R
to make sure the analysis variableEVNT1
has both levels of the factor defined.  Improved error message when number of levels in a factor variable in a data frame is not as expected.
tern 0.7.1
 New argument
position_surv_med
added tog_km
to move position of the annotation table with median survival times.  Fixed bug in
g_km
related to the ignored argumentspch
andsize
which were not passed on to helper functionh_ggkm
.  Updated
xticks
andmax_time
arguments ing_km
for greater functionality.max_time
added as an argument inh_xticks
to allow this.  Fixed bug in
prop_diff_cmh
that led toNaN
weighted proportion difference estimates and missing confidence intervals. Before this change, when including no patients from one treatment arm for at least one stratum the estimation did not lead to numeric results.  Fixed bug in
prop_cmh
giving an error in case of at least one stratum containing less than two observations.  New argument
n_events
added toestimate_incidence_rate
.  New argument
denom
added tocount_occurrences
.  New arguments
yval
andci_ribbon
added tog_km
.  Add new individual patient plot function
g_ipp
along with helpersh_g_ipp
andh_set_nest_theme
.  Fixed bug in
count_patients_with_events
, now shows zero counts without percentage.  Fixed bug in
get_mmrm_lsmeans
which did not allowMMRM
analysis of more than 3000 observations.  Updated
stat_mean_ci
andstat_median_ci
to handle edge cases with number of elements in input series equal to 1. For such cases,NA_real_
is now returned, instead ofNA
or+/Inf
for confidence interval (CI) estimates.  Rename
n_lim
argument ofstat_mean_ci
ton_min
to better reflect its desired meaning.
tern 0.7.0
This version of tern
introduces a major rewriting of tern
due to the change to layout based tabulation in rtables
. tern
now does not build tables directly anymore, instead it provides analysis functions to build tables, see the examples. * Counting patients with abnormal values postbaseline with count_abnormal
. * Counting patients with graded abnormal values with count_abnormal_by_worst_grade
. * Counting patients with abnormal values by baseline status with count_abnormal_by_baseline
. * Counting patients with missed doses with s_count_missed_doses
and count_missed_doses
. * Counting patients with event flags with count_patients_with_event
and count_patients_with_flags
. * Summarizing variables with summarize_vars
(supports numeric, factor, character and logical variables). Note that factors need to have NA
s converted to na_level
before use. * Summarizing change from baseline with summarize_change
. * Summarizing variables in columns with summarize_colvars
. * Estimating difference for responder proportions with estimate_proportion_diff
. * Estimating difference for Odds Ratio with estimate_odds_ratio
. * Testing the difference in responder proportions with test_proportion_diff
. * Estimating the responder proportion for the level of a factor with estimate_multinomial_response
. * Fitting and tabulating the results of Cox regressions with fit_coxreg_univar
, fit_coxreg_multivar
and summarize_coxreg
, respectively. * Pruning occurrence tables (or tables with counts and fractions) with flexible rules, see ?prune_occurrences
for details. * Sorting occurrence tables using different options, see ?score_occurrences
for details. * Fitting and tabulating MMRM
models with fit_mmrm
and as.rtable
and summarize_lsmeans
, see ?tabulate_mmrm
for details. * Counting the number of unique and nonunique patients with summarize_num_patients
. * Counting occurrences with count_occurrences
. * Counting occurrences by grade with summarize_occurrences_by_grade
and count_occurrences_by_grade
. * Counting patients and events in columns with summarize_patients_events_in_cols
. * Tabulating the binary outcome response by subgroup with extract_rsp_subgroups
and tabulate_rsp_subgroups
. * Tabulating the survival duration by subgroup with extract_survival_subgroups
and tabulate_survival_subgroups
.
tern 0.6.8
 Improved handling of missing data in aggregation functions:
a_mean_sd
,a_median
,a_n_true_and_freq
,a_count
,a_q1q3
,a_iqr
,a_range
.  New default pvalue method in
s_test_proportion_diff
: ChiSquared Test with Schouten Correction.  Add new function
t_contingency
for contingency tables.  Renamed the class
splitText
todynamicSplitText
to resolve the name conflict with the packageggpubr
.  Add
rreplace_format
for tabulation postprocessing.  Add new tern function
t_ancova
to createANCOVA
tables, as well as corresponding elementary table functiont_el_ancova
and summary functions_ancova
.  Add new tern function
s_odds_ratio
to estimate Odds Ratio of response between categories, as well as the corresponding elementary table functiont_el_odds_ratio
.  Added new CI methods (
AgrestiCoull
,Jeffreys
) fors_proportion
.  Added new CI methods
andersonhauck
andnewcombe
tos_proportion_diff
.  Added new pvalue methods (Fisher’s Exact, ChiSquared Test with Schouten Correction) for
s_test_proportion_diff
.  The binary summary table function
t_binary_outcome
takes now lists (instead of character vectors) specified by the helper functioncontrol_binary_comparison
as the argumentsstrat_analysis
andunstrat_analysis
. Odds Ratio estimates and CIs are now removable and included by default, similarly to the other subsections of the arm comparison analyses. Also added argumentrsp_multinomial
.  Add new table function
t_el_multinomial_proportion
.  Add new table function
t_abn_shift
.  Add new
MMRM
analysis functions_mmrm
, as well as corresponding table functionst_mmrm_lsmeans
,t_mmrm_cov
,t_mmrm_diagnostic
,t_mmrm_fixed
, and plot functionsg_mmrm_lsmeans
,g_mmrm_diagnostic
. The results of these match SAS results (up to numeric precision).  Deprecated old
MMRM
functionsa_mmrm
andt_mmrm
(they give a deprecation warning but still work) to remove in the next release. The reason is that the results of these functions don’t match SAS results.  Fix bug in
g_km
related to numbers in patients at risk table to correct numbers for integer timetoevent variable inputs.
tern 0.6.7
 For functions with
row_by
argument, inputs no longer require use ofnested_by
.  Add
stat_mean_ci
andstat_median_ci
for error bars inggplot2
.  Add new tern function
t_coxreg
as single interface for diverse cox regression types.  Add compound table for binary endpoint:
t_binary_endpoint
and elementary functions:t_el_proportion
,t_el_proportion_diff
andt_el_test_proportion_diff
. The supporting summary functions added are:s_proportion
,s_adj_proportion_diff
,s_proportion_diff
ands_test_proportion_diff
.  Added new tern function
t_events_patyear
to create event table adjusted personyears.  Added new tern function
t_abnormality
and the elementary table functiont_el_abnormality
.  Removed
grade_levels
argument fromt_events_term_grade_id
functions. Postprocessing by reordering the leaves of the table tree creates a different ordering of rows if required. Creating a helper function will occur at a later time.  Added
prune_zero_rows
argument tot_events_per_term_grade_id
andt_max_grade_per_id
to not show rows of all zeros as they can clutter the visualization in the Shiny app and make it slower.  Fixed position of (N=xx) in
t_summary_by
output when summarizing numeric columns in parallel withcompare_in_header
.  Rename
t_coxph
tot_coxph_pairwise
to reflect the model process, add details in documentation.  Remove
test.nest
dependency.  Keep column labels when splitting data into tree.
tern 0.6.5
 Change default option for denominator to be
N
int_summary
.  Fix IQR bug: IQR as Q3 minus Q1.
 Add new function
t_logistic
for multivariable logistic regression table.  Add new function
df_explicit_na
to replaceNA
by explicit values.  Added possibility in
t_tte
to specify confidence level independent forsurvfit
,coxph
, andztest
, see the manual.  Fixed bug in
t_rsp
of not showing pvalue, odds ratio and CIs whenstrata_data
is notNULL
.  Added stratified analysis for
t_forest_rsp
andt_forest_tte
, with footnotes ing_forest
.  Added
footnotes
,footnotes<
andadd_footnotes<
functions to deal with footnotes.  Added argument
conf_int
for confidence interval level tot_el_forest_rps
,t_forest_rsp
,t_el_forest_tte
,t_forest_tte
.  Added argument
col_symbol_size
tog_forest
to control the relative size of symbols used in the plot.  Added
s_coxph_pairwise
function to perform pairwise testing, used byt_tte
andt_coxph
.  Added methods for
t_count_true
replacingt_summary_true
.  Updated
t_count_unique
to create analysis subsets, addedt_el_count_unique
for vectors.  Fixed bug in
t_events_term_id
so that table sort order is by decreasing frequency instead of alphabetical.  Added function
color_palette
and a new nest color palette.
tern 0.6.4
 Refactored after renaming functions in
utils.nest
.  Added
event_type
argument tot_events_per_term_grade_id
.  Added one/twoarm ttest functions.
 Improvements in
t_summary_by
.  Internal code refactoring.
tern 0.6.3
 Added
node
S4 class to create trees: For all related tree functions see the reference under trees.
 Removed functions:
 Moved all the label functions to
rtables
.  Deleted
keys
andkeys<
functions.
 Moved all the label functions to
 New helper functions:
 Exported
tabulate_pairwise
. 
get_N
,col_N_add_total
,check_id
. 
na_as_level
. 
as_factor_keep_attributes
. 
r_by
.
 Exported
 New TLGs:
 Disposition elementary table
t_el_disposition
. 
t_el_forest_tte
,t_el_forest_rsp
.
 Disposition elementary table
 Changed Arguments:
 All compound tables:
 Added
table_tree
argument which returns anode
object.
 Added

t_summary.numeric
: Added
f_numeric
to choose which statistics to calculate.
 Added

t_summary.factor
:
denominator
now also allows foromit
if wanting to omit percentages.


t_summary_by
: Renamed
by
torow_by
.
 Renamed

t_forest_rsp
,t_forest_tte
: Changed functionality of
group_data
usingrow_by_list
.  Removed
na_omit_group
.
 Changed functionality of

t_count_unique
: Removed
indent
argument, use theindent
function inrtables
. instead
 Removed
 All compound tables:
tern 0.6.2
 Use cached data from
random.cdisc.data
to speed up testing.  Added
t_summary.Date
method.  Added
save_join
.
tern 0.6.1
 Fixed colors in KaplanMeier Plot
 Refactor of all functions to pass
test.nest
tests: Changed
width_row.names
argument ofg_forest
function intowidth_row_names
.  Changed
censor.show
argument ofg_km
function intocensor_show
.  Changed
col.legend.title
argument ofg_waterfall
function intocol_legend_title
.  Changed
na.rm
argument oft_count_unique
function intona_rm
.  Changed
row.name
argument oft_count_unique
function intorow_name
.  Changed
na.omit.group
argument oft_forest_rsp
function intona_omit_group
.  Changed
na.omit.group
argument oft_forest_tte
function intona_omit_group
.  Changed
row.name.TRUE
androw.name.FALSE
arguments oft_summary.logical
intorow_name_true
androw_name_false
respectively.  Rename
splotTextGrob
intosplit_text_grob
.  Fix examples.
 Refactor of internal functions code.
 Changed
tern 0.6.0
 Removed functions
addTable
,t_summarize_by_visit
,t_summarize_variables
.  Added
t_summary_by
function.  Refactor of
g_km
function, renamedkmGrob
intokmCurveGrob
.  Refactor
t_events_*
family of functions.  Updated examples.
tern 0.5.0.3
New TLGs

t_summary
and methods fordata.frame
,numeric
,logical
,character
,factor
, andDate
objects. 
t_events_per_term_id
,t_events_per_term_grade_id
: Adverse Events & Concomitant Treatment Tables. 
t_max_grade_per_id
,t_count_unique
,t_events_summary
elementary tables used for the Adverse Events & Concomitant Treatment Tables. 
g_waterfall
: Horizontal Waterfall Plot.
New Helper Functions

decorate_grob
,decorate_grob_set
,decorate_grob_factory
,splitTextGrob
. 
stack_grobs
,arrange_grobs
,draw_grob
.
TLG changes

t_tte
now shows two rows with ranges for event and censored times, respectively. 
g_km
works with one armsurvfit
objects.  In forest plot functions, added formatting to display extreme values to “>999.9”.

t_summarise_variables
uses nown
instead ofN
as a denominator for calculating percentages for factors by default. 
t_rsp
now works when all response values areTRUE
orFALSE
.