This function creates a data set with a single simulated oncology clinical trial with one row per transition based on an illness-death model. Studies with an arbitrary number of treatment arms are possible.
Arguments
- nPat
(
integer)
numbers of patients per treatment arm.- transitionByArm
(
list)
transition parameters for each treatment group. Seeexponential_transition(),piecewise_exponential()andweibull_transition()for details.- dropout
dropout (
list)
specifies drop-out probability. SeegetSimulatedData()for details. Can be specified either as one list that should be applied to all treatment groups or a separate list for each treatment group.- accrual
accrual (
list)
specifies accrual intensity. SeeaddStaggeredEntry()for details. Can be specified either as one list that should be applied to all treatment groups or a separate list for each treatment group.
Value
This returns a data frame with one simulated clinical trial and multiple treatment arms.
See getSimulatedData() for the explanation of the columns. The column trt contains the treatment indicator.
This is a helper function of getClinicalTrials().
Examples
transition1 <- exponential_transition(h01 = 1.2, h02 = 1.5, h12 = 1.6)
transition2 <- exponential_transition(h01 = 1, h02 = 1.3, h12 = 1.7)
transition3 <- exponential_transition(h01 = 1.1, h02 = 1, h12 = 1.5)
getOneClinicalTrial(
nPat = c(30, 20, 30), transitionByArm = list(transition1, transition2, transition3),
dropout = list(rate = 0, time = 12),
accrual = list(param = "time", value = 0)
)
#> id from to entry exit entryAct exitAct censAct trt
#> 1 1 0 1 0.000000000 1.041846534 0.000000000 1.041846534 Inf 1
#> 2 1 1 2 1.041846534 1.785545401 1.041846534 1.785545401 Inf 1
#> 3 2 0 2 0.000000000 0.477939717 0.000000000 0.477939717 Inf 1
#> 4 3 0 2 0.000000000 0.198632402 0.000000000 0.198632402 Inf 1
#> 5 4 0 1 0.000000000 0.836504820 0.000000000 0.836504820 Inf 1
#> 6 4 1 2 0.836504820 1.675281116 0.836504820 1.675281116 Inf 1
#> 7 5 0 1 0.000000000 0.144586256 0.000000000 0.144586256 Inf 1
#> 8 5 1 2 0.144586256 0.377156364 0.144586256 0.377156364 Inf 1
#> 9 6 0 2 0.000000000 0.738316279 0.000000000 0.738316279 Inf 1
#> 10 7 0 1 0.000000000 0.324248942 0.000000000 0.324248942 Inf 1
#> 11 7 1 2 0.324248942 0.584568619 0.324248942 0.584568619 Inf 1
#> 12 8 0 1 0.000000000 0.120698069 0.000000000 0.120698069 Inf 1
#> 13 8 1 2 0.120698069 0.239101297 0.120698069 0.239101297 Inf 1
#> 14 9 0 1 0.000000000 0.379847986 0.000000000 0.379847986 Inf 1
#> 15 9 1 2 0.379847986 2.304839337 0.379847986 2.304839337 Inf 1
#> 16 10 0 1 0.000000000 0.550436302 0.000000000 0.550436302 Inf 1
#> 17 10 1 2 0.550436302 0.954895366 0.550436302 0.954895366 Inf 1
#> 18 11 0 1 0.000000000 0.065405460 0.000000000 0.065405460 Inf 1
#> 19 11 1 2 0.065405460 0.432720658 0.065405460 0.432720658 Inf 1
#> 20 12 0 1 0.000000000 0.416168752 0.000000000 0.416168752 Inf 1
#> 21 12 1 2 0.416168752 0.425586299 0.416168752 0.425586299 Inf 1
#> 22 13 0 1 0.000000000 0.848635343 0.000000000 0.848635343 Inf 1
#> 23 13 1 2 0.848635343 1.345220684 0.848635343 1.345220684 Inf 1
#> 24 14 0 2 0.000000000 0.293636775 0.000000000 0.293636775 Inf 1
#> 25 15 0 1 0.000000000 0.190591749 0.000000000 0.190591749 Inf 1
#> 26 15 1 2 0.190591749 0.410027811 0.190591749 0.410027811 Inf 1
#> 27 16 0 2 0.000000000 0.074930422 0.000000000 0.074930422 Inf 1
#> 28 17 0 2 0.000000000 0.799729649 0.000000000 0.799729649 Inf 1
#> 29 18 0 1 0.000000000 0.473761520 0.000000000 0.473761520 Inf 1
#> 30 18 1 2 0.473761520 0.856473293 0.473761520 0.856473293 Inf 1
#> 31 19 0 2 0.000000000 0.623404745 0.000000000 0.623404745 Inf 1
#> 32 20 0 1 0.000000000 0.276036099 0.000000000 0.276036099 Inf 1
#> 33 20 1 2 0.276036099 0.378378385 0.276036099 0.378378385 Inf 1
#> 34 21 0 2 0.000000000 0.248112642 0.000000000 0.248112642 Inf 1
#> 35 22 0 2 0.000000000 0.166077237 0.000000000 0.166077237 Inf 1
#> 36 23 0 2 0.000000000 0.119202878 0.000000000 0.119202878 Inf 1
#> 37 24 0 1 0.000000000 0.638967936 0.000000000 0.638967936 Inf 1
#> 38 24 1 2 0.638967936 1.648969622 0.638967936 1.648969622 Inf 1
#> 39 25 0 1 0.000000000 0.485001721 0.000000000 0.485001721 Inf 1
#> 40 25 1 2 0.485001721 1.425102016 0.485001721 1.425102016 Inf 1
#> 41 26 0 2 0.000000000 0.677533459 0.000000000 0.677533459 Inf 1
#> 42 27 0 2 0.000000000 0.424758013 0.000000000 0.424758013 Inf 1
#> 43 28 0 1 0.000000000 0.612796632 0.000000000 0.612796632 Inf 1
#> 44 28 1 2 0.612796632 0.768975224 0.612796632 0.768975224 Inf 1
#> 45 29 0 2 0.000000000 0.063063325 0.000000000 0.063063325 Inf 1
#> 46 30 0 1 0.000000000 0.001675383 0.000000000 0.001675383 Inf 1
#> 47 30 1 2 0.001675383 0.014149445 0.001675383 0.014149445 Inf 1
#> 48 31 0 2 0.000000000 0.376999758 0.000000000 0.376999758 Inf 2
#> 49 32 0 1 0.000000000 0.004662485 0.000000000 0.004662485 Inf 2
#> 50 32 1 2 0.004662485 2.686381115 0.004662485 2.686381115 Inf 2
#> 51 33 0 2 0.000000000 0.549150618 0.000000000 0.549150618 Inf 2
#> 52 34 0 2 0.000000000 0.252850824 0.000000000 0.252850824 Inf 2
#> 53 35 0 2 0.000000000 0.048971014 0.000000000 0.048971014 Inf 2
#> 54 36 0 2 0.000000000 1.190994143 0.000000000 1.190994143 Inf 2
#> 55 37 0 1 0.000000000 0.387723021 0.000000000 0.387723021 Inf 2
#> 56 37 1 2 0.387723021 1.677378489 0.387723021 1.677378489 Inf 2
#> 57 38 0 2 0.000000000 0.153998393 0.000000000 0.153998393 Inf 2
#> 58 39 0 2 0.000000000 0.140612650 0.000000000 0.140612650 Inf 2
#> 59 40 0 2 0.000000000 0.115334711 0.000000000 0.115334711 Inf 2
#> 60 41 0 2 0.000000000 1.117426714 0.000000000 1.117426714 Inf 2
#> 61 42 0 2 0.000000000 0.369076069 0.000000000 0.369076069 Inf 2
#> 62 43 0 1 0.000000000 0.619694733 0.000000000 0.619694733 Inf 2
#> 63 43 1 2 0.619694733 0.747321687 0.619694733 0.747321687 Inf 2
#> 64 44 0 2 0.000000000 0.069418866 0.000000000 0.069418866 Inf 2
#> 65 45 0 2 0.000000000 0.018769671 0.000000000 0.018769671 Inf 2
#> 66 46 0 2 0.000000000 0.180340436 0.000000000 0.180340436 Inf 2
#> 67 47 0 1 0.000000000 0.748051530 0.000000000 0.748051530 Inf 2
#> 68 47 1 2 0.748051530 0.826597896 0.748051530 0.826597896 Inf 2
#> 69 48 0 2 0.000000000 1.073077454 0.000000000 1.073077454 Inf 2
#> 70 49 0 2 0.000000000 0.383623952 0.000000000 0.383623952 Inf 2
#> 71 50 0 2 0.000000000 0.341823002 0.000000000 0.341823002 Inf 2
#> 72 51 0 2 0.000000000 1.324966440 0.000000000 1.324966440 Inf 3
#> 73 52 0 1 0.000000000 0.227653135 0.000000000 0.227653135 Inf 3
#> 74 52 1 2 0.227653135 0.640835097 0.227653135 0.640835097 Inf 3
#> 75 53 0 1 0.000000000 0.026038723 0.000000000 0.026038723 Inf 3
#> 76 53 1 2 0.026038723 0.636689636 0.026038723 0.636689636 Inf 3
#> 77 54 0 2 0.000000000 0.155402816 0.000000000 0.155402816 Inf 3
#> 78 55 0 1 0.000000000 0.072191253 0.000000000 0.072191253 Inf 3
#> 79 55 1 2 0.072191253 0.556745505 0.072191253 0.556745505 Inf 3
#> 80 56 0 1 0.000000000 0.727734457 0.000000000 0.727734457 Inf 3
#> 81 56 1 2 0.727734457 1.128613158 0.727734457 1.128613158 Inf 3
#> 82 57 0 2 0.000000000 0.096652997 0.000000000 0.096652997 Inf 3
#> 83 58 0 2 0.000000000 1.041313011 0.000000000 1.041313011 Inf 3
#> 84 59 0 1 0.000000000 0.031554070 0.000000000 0.031554070 Inf 3
#> 85 59 1 2 0.031554070 0.378476550 0.031554070 0.378476550 Inf 3
#> 86 60 0 2 0.000000000 1.049345811 0.000000000 1.049345811 Inf 3
#> 87 61 0 2 0.000000000 1.274462026 0.000000000 1.274462026 Inf 3
#> 88 62 0 1 0.000000000 0.262239182 0.000000000 0.262239182 Inf 3
#> 89 62 1 2 0.262239182 1.185368013 0.262239182 1.185368013 Inf 3
#> 90 63 0 2 0.000000000 0.901371136 0.000000000 0.901371136 Inf 3
#> 91 64 0 2 0.000000000 0.009099860 0.000000000 0.009099860 Inf 3
#> 92 65 0 2 0.000000000 1.173042134 0.000000000 1.173042134 Inf 3
#> 93 66 0 2 0.000000000 0.218041763 0.000000000 0.218041763 Inf 3
#> 94 67 0 2 0.000000000 0.150703354 0.000000000 0.150703354 Inf 3
#> 95 68 0 2 0.000000000 0.176833163 0.000000000 0.176833163 Inf 3
#> 96 69 0 2 0.000000000 0.363713581 0.000000000 0.363713581 Inf 3
#> 97 70 0 2 0.000000000 0.290230965 0.000000000 0.290230965 Inf 3
#> 98 71 0 2 0.000000000 0.965436826 0.000000000 0.965436826 Inf 3
#> 99 72 0 2 0.000000000 1.290563037 0.000000000 1.290563037 Inf 3
#> 100 73 0 1 0.000000000 0.921337732 0.000000000 0.921337732 Inf 3
#> 101 73 1 2 0.921337732 1.411323176 0.921337732 1.411323176 Inf 3
#> 102 74 0 1 0.000000000 0.370194057 0.000000000 0.370194057 Inf 3
#> 103 74 1 2 0.370194057 0.998483516 0.370194057 0.998483516 Inf 3
#> 104 75 0 2 0.000000000 0.593267184 0.000000000 0.593267184 Inf 3
#> 105 76 0 2 0.000000000 0.087529620 0.000000000 0.087529620 Inf 3
#> 106 77 0 2 0.000000000 0.394015487 0.000000000 0.394015487 Inf 3
#> 107 78 0 1 0.000000000 0.473727459 0.000000000 0.473727459 Inf 3
#> 108 78 1 2 0.473727459 0.489373740 0.473727459 0.489373740 Inf 3
#> 109 79 0 1 0.000000000 0.062052474 0.000000000 0.062052474 Inf 3
#> 110 79 1 2 0.062052474 0.130825736 0.062052474 0.130825736 Inf 3
#> 111 80 0 1 0.000000000 0.138737238 0.000000000 0.138737238 Inf 3
#> 112 80 1 2 0.138737238 0.811405377 0.138737238 0.811405377 Inf 3