LBT14 Table 1 (Low Direction) Laboratory Test Results Shift Table – Highest NCI-CTCAE Grade Post-Baseline by
Baseline Grade.
lbt14_1.RdLBT14 Table 1 (Low Direction) Laboratory Test Results Shift Table – Highest NCI-CTCAE Grade Post-Baseline by
Baseline Grade.
Usage
lbt14_1_main(
adam_db,
arm_var = "ACTARM",
gr_missing = "incl",
title = "LBT14 - Low Direction",
deco = std_deco("LBT14"),
...
)
lbt14_1_lyt(arm_var, gr_missing, title, deco)
lbt14_1_pre(
adam_db,
gr_missing = "incl",
req_tables = c("adsl", "adlb"),
arm_var = "ACTARM",
...
)
lbt14_1_check(adam_db, req_tables = c("adsl", "adlb"), arm_var = "ACTARM")
lbt14_1_post(tlg, prune_0 = TRUE, ...)
lbt14_1Arguments
- adam_db
(
dm) object containing theADaMdatasets- arm_var
(
string) variable used for column splitting- gr_missing
how missing baseline grades should be handled. Defaults to
"incl"to include the"Missing"level. Other options are"excl"to exclude patients with missing baseline grades and"gr_0"to convert missing baseline grades to grade 0.- title
table title to display. Defaults to
"LBT14 - Low Direction".- deco
(
character) decoration withtitle,subtitlesandmain_footercontent- ...
not used.
- req_tables
(
character) names of the required tables.- tlg
(
TableTree,Listingorggplot) object typically produced by amainfunction.- prune_0
(
flag) remove 0 count rows
Details
Only the worst grade recorded for each patient is included in the table.
If no missing baseline lab results, the "Missing" level of
BTOXGRis excluded.Grades 0, 1, 2, 3, and 4 are counted as
"Not Low".Remove zero-count rows unless overridden with
prune_0 = FALSE.Split columns by arm, typically
ACTARM.
Functions
lbt14_1_main(): Main TLG functionlbt14_1_lyt(): Layoutlbt14_1_pre(): Preprocessinglbt14_1_check(): Checkslbt14_1_post(): Postprocessing
Note
adam_dbobject must contain anadlbtable with columns"USUBJID","PARAM","BTOXGR","ATOXGR", and the column specified byarm_var.
Examples
run(lbt14_1, syn_data)
#> LBT14 - Low Direction
#>
#>
#> ——————————————————————————————————————————————————————————————————————————————————————
#> Parameter
#> Baseline NCI-CTCAE Grade A: Drug X B: Placebo C: Combination
#> Post-baseline NCI-CTCAE Grade (N=134) (N=134) (N=132)
#> ——————————————————————————————————————————————————————————————————————————————————————
#> Alanine Aminotransferase Measurement
#> Not Low 124 122 117
#> Not Low 74 (59.7%) 76 (62.3%) 80 (68.4%)
#> 1 13 (10.5%) 12 (9.8%) 9 (7.7%)
#> 2 13 (10.5%) 16 (13.1%) 11 (9.4%)
#> 3 17 (13.7%) 11 (9.0%) 9 (7.7%)
#> 4 7 (5.6%) 7 (5.7%) 8 (6.8%)
#> 1 3 6 7
#> Not Low 0 2 (33.3%) 5 (71.4%)
#> 1 1 (33.3%) 2 (33.3%) 0
#> 2 0 1 (16.7%) 0
#> 3 2 (66.7%) 1 (16.7%) 0
#> 4 0 0 2 (28.6%)
#> 2 2 1 4
#> Not Low 2 (100%) 0 3 (75.0%)
#> 2 0 1 (100%) 0
#> 3 0 0 1 (25.0%)
#> 3 2 3 4
#> Not Low 2 (100%) 2 (66.7%) 3 (75.0%)
#> 1 0 1 (33.3%) 1 (25.0%)
#> 4 3 2 0
#> Not Low 2 (66.7%) 1 (50.0%) 0
#> 3 1 (33.3%) 0 0
#> 4 0 1 (50.0%) 0
#> C-Reactive Protein Measurement
#> Not Low 122 125 120
#> Not Low 67 (54.9%) 81 (64.8%) 70 (58.3%)
#> 1 14 (11.5%) 17 (13.6%) 13 (10.8%)
#> 2 20 (16.4%) 11 (8.8%) 16 (13.3%)
#> 3 12 (9.8%) 9 (7.2%) 17 (14.2%)
#> 4 9 (7.4%) 7 (5.6%) 4 (3.3%)
#> 1 2 5 5
#> Not Low 0 3 (60.0%) 4 (80.0%)
#> 1 0 1 (20.0%) 1 (20.0%)
#> 2 1 (50.0%) 1 (20.0%) 0
#> 4 1 (50.0%) 0 0
#> 2 5 1 1
#> Not Low 3 (60.0%) 0 1 (100%)
#> 1 2 (40.0%) 0 0
#> 2 0 1 (100%) 0
#> 3 2 2 1
#> Not Low 2 (100%) 1 (50.0%) 0
#> 1 0 1 (50.0%) 0
#> 3 0 0 1 (100%)
#> 4 3 1 5
#> Not Low 2 (66.7%) 1 (100%) 3 (60.0%)
#> 1 0 0 1 (20.0%)
#> 4 1 (33.3%) 0 1 (20.0%)
#> Immunoglobulin A Measurement
#> Not Low 120 119 120
#> Not Low 69 (57.5%) 58 (48.7%) 70 (58.3%)
#> 1 16 (13.3%) 20 (16.8%) 16 (13.3%)
#> 2 12 (10.0%) 14 (11.8%) 14 (11.7%)
#> 3 14 (11.7%) 11 (9.2%) 13 (10.8%)
#> 4 9 (7.5%) 16 (13.4%) 7 (5.8%)
#> 1 8 8 3
#> Not Low 7 (87.5%) 4 (50.0%) 2 (66.7%)
#> 1 1 (12.5%) 3 (37.5%) 0
#> 2 0 1 (12.5%) 0
#> 4 0 0 1 (33.3%)
#> 2 2 1 2
#> Not Low 2 (100%) 1 (100%) 2 (100%)
#> 3 3 3 4
#> Not Low 1 (33.3%) 3 (100%) 2 (50.0%)
#> 1 0 0 1 (25.0%)
#> 3 1 (33.3%) 0 0
#> 4 1 (33.3%) 0 1 (25.0%)
#> 4 1 3 3
#> Not Low 1 (100%) 3 (100%) 1 (33.3%)
#> 3 0 0 1 (33.3%)
#> 4 0 0 1 (33.3%)