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LBT14 Table 1 (Low Direction) Laboratory Test Results Shift Table – Highest NCI-CTCAE Grade Post-Baseline by Baseline Grade.

Usage

lbt14_1_main(
  adam_db,
  arm_var = "ACTARM",
  gr_missing = "incl",
  title = "LBT14 - Low Direction",
  deco = std_deco("LBT14"),
  ...
)

lbt14_1_lyt(arm_var, gr_missing, title, deco)

lbt14_1_pre(
  adam_db,
  gr_missing = "incl",
  req_tables = c("adsl", "adlb"),
  arm_var = "ACTARM",
  ...
)

lbt14_1_check(adam_db, req_tables = c("adsl", "adlb"), arm_var = "ACTARM")

lbt14_1_post(tlg, prune_0 = TRUE, ...)

lbt14_1

Format

An object of class chevron_t of length 1.

Arguments

adam_db

(dm) object containing the ADaM datasets

arm_var

(string) variable used for column splitting

gr_missing

how missing baseline grades should be handled. Defaults to "incl" to include the "Missing" level. Other options are "excl" to exclude patients with missing baseline grades and "gr_0" to convert missing baseline grades to grade 0.

title

table title to display. Defaults to "LBT14 - Low Direction".

deco

(character) decoration with title, subtitles and main_footer content

...

not used.

req_tables

(character) names of the required tables.

tlg

(TableTree, Listing or ggplot) object typically produced by a main function.

prune_0

(flag) remove 0 count rows

Details

  • Only the worst grade recorded for each patient is included in the table.

  • If no missing baseline lab results, the "Missing" level of BTOXGR is excluded.

  • Grades 0, 1, 2, 3, and 4 are counted as "Not Low".

  • Remove zero-count rows unless overridden with prune_0 = FALSE.

  • Split columns by arm, typically ACTARM.

Functions

  • lbt14_1_main(): Main TLG function

  • lbt14_1_lyt(): Layout

  • lbt14_1_pre(): Preprocessing

  • lbt14_1_check(): Checks

  • lbt14_1_post(): Postprocessing

Note

  • adam_db object must contain an adlb table with columns "USUBJID", "PARAM", "BTOXGR", "ATOXGR", and the column specified by arm_var.

Examples

run(lbt14_1, syn_data)
#> LBT14 - Low Direction
#> 
#> 
#>   ——————————————————————————————————————————————————————————————————————————————————————
#>   Parameter                                                                             
#>         Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
#>                 Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
#>   ——————————————————————————————————————————————————————————————————————————————————————
#>   Alanine Aminotransferase Measurement                                                  
#>         Not Low                                    124          122            117      
#>                 Not Low                         74 (59.7%)   76 (62.3%)     80 (68.4%)  
#>                 1                               13 (10.5%)   12 (9.8%)       9 (7.7%)   
#>                 2                               13 (10.5%)   16 (13.1%)     11 (9.4%)   
#>                 3                               17 (13.7%)   11 (9.0%)       9 (7.7%)   
#>                 4                                7 (5.6%)     7 (5.7%)       8 (6.8%)   
#>         1                                           3            6              7       
#>                 Not Low                             0        2 (33.3%)      5 (71.4%)   
#>                 1                               1 (33.3%)    2 (33.3%)          0       
#>                 2                                   0        1 (16.7%)          0       
#>                 3                               2 (66.7%)    1 (16.7%)          0       
#>                 4                                   0            0          2 (28.6%)   
#>         2                                           2            1              4       
#>                 Not Low                          2 (100%)        0          3 (75.0%)   
#>                 2                                   0         1 (100%)          0       
#>                 3                                   0            0          1 (25.0%)   
#>         3                                           2            3              4       
#>                 Not Low                          2 (100%)    2 (66.7%)      3 (75.0%)   
#>                 1                                   0        1 (33.3%)      1 (25.0%)   
#>         4                                           3            2              0       
#>                 Not Low                         2 (66.7%)    1 (50.0%)          0       
#>                 3                               1 (33.3%)        0              0       
#>                 4                                   0        1 (50.0%)          0       
#>   C-Reactive Protein Measurement                                                        
#>         Not Low                                    122          125            120      
#>                 Not Low                         67 (54.9%)   81 (64.8%)     70 (58.3%)  
#>                 1                               14 (11.5%)   17 (13.6%)     13 (10.8%)  
#>                 2                               20 (16.4%)   11 (8.8%)      16 (13.3%)  
#>                 3                               12 (9.8%)     9 (7.2%)      17 (14.2%)  
#>                 4                                9 (7.4%)     7 (5.6%)       4 (3.3%)   
#>         1                                           2            5              5       
#>                 Not Low                             0        3 (60.0%)      4 (80.0%)   
#>                 1                                   0        1 (20.0%)      1 (20.0%)   
#>                 2                               1 (50.0%)    1 (20.0%)          0       
#>                 4                               1 (50.0%)        0              0       
#>         2                                           5            1              1       
#>                 Not Low                         3 (60.0%)        0           1 (100%)   
#>                 1                               2 (40.0%)        0              0       
#>                 2                                   0         1 (100%)          0       
#>         3                                           2            2              1       
#>                 Not Low                          2 (100%)    1 (50.0%)          0       
#>                 1                                   0        1 (50.0%)          0       
#>                 3                                   0            0           1 (100%)   
#>         4                                           3            1              5       
#>                 Not Low                         2 (66.7%)     1 (100%)      3 (60.0%)   
#>                 1                                   0            0          1 (20.0%)   
#>                 4                               1 (33.3%)        0          1 (20.0%)   
#>   Immunoglobulin A Measurement                                                          
#>         Not Low                                    120          119            120      
#>                 Not Low                         69 (57.5%)   58 (48.7%)     70 (58.3%)  
#>                 1                               16 (13.3%)   20 (16.8%)     16 (13.3%)  
#>                 2                               12 (10.0%)   14 (11.8%)     14 (11.7%)  
#>                 3                               14 (11.7%)   11 (9.2%)      13 (10.8%)  
#>                 4                                9 (7.5%)    16 (13.4%)      7 (5.8%)   
#>         1                                           8            8              3       
#>                 Not Low                         7 (87.5%)    4 (50.0%)      2 (66.7%)   
#>                 1                               1 (12.5%)    3 (37.5%)          0       
#>                 2                                   0        1 (12.5%)          0       
#>                 4                                   0            0          1 (33.3%)   
#>         2                                           2            1              2       
#>                 Not Low                          2 (100%)     1 (100%)       2 (100%)   
#>         3                                           3            3              4       
#>                 Not Low                         1 (33.3%)     3 (100%)      2 (50.0%)   
#>                 1                                   0            0          1 (25.0%)   
#>                 3                               1 (33.3%)        0              0       
#>                 4                               1 (33.3%)        0          1 (25.0%)   
#>         4                                           1            3              3       
#>                 Not Low                          1 (100%)     3 (100%)      1 (33.3%)   
#>                 3                                   0            0          1 (33.3%)   
#>                 4                                   0            0          1 (33.3%)