LBT14 Table 2 (High Direction) Laboratory Test Results Shift Table – Highest NCI-CTCAE Grade Post-Baseline by
Baseline Grade.
lbt14_2.RdLBT14 Table 2 (High Direction) Laboratory Test Results Shift Table – Highest NCI-CTCAE Grade Post-Baseline by
Baseline Grade.
Usage
lbt14_2_main(
adam_db,
arm_var = "ACTARM",
gr_missing = "incl",
title = "LBT14 - High Direction",
deco = std_deco("LBT14"),
...
)
lbt14_2_lyt(arm_var, gr_missing, title, deco)
lbt14_2_pre(
adam_db,
gr_missing = "incl",
req_tables = c("adsl", "adlb"),
arm_var = "ACTARM",
...
)
lbt14_2_check(adam_db, req_tables = c("adsl", "adlb"), arm_var = "ACTARM")
lbt14_2_post(tlg, prune_0 = TRUE, ...)
lbt14_2Arguments
- adam_db
(
dm) object containing theADaMdatasets- arm_var
(
character) variable used for column splitting- gr_missing
how missing baseline grades should be handled. Defaults to
"incl"to include the"Missing"level. Other options are"excl"to exclude patients with missing baseline grades and"gr_0"to convert missing baseline grades to grade 0.- title
table title to display. Defaults to
"LBT14 - High Direction".- deco
(
character) decoration withtitle,subtitlesandmain_footercontent- ...
not used.
- req_tables
(
character) names of the required tables.- tlg
(
TableTree,Listingorggplot) object typically produced by amainfunction.- prune_0
(
logical) remove 0 count rows
Details
Only the worst grade recorded for each patient is included in the table.
If no missing baseline lab results, the "Missing" level of
BTOXGRis excluded.Grades 0, -1, -2, -3, and -4 are counted as
"Not High".Remove zero-count rows unless overridden with
prune_0 = FALSE.Split columns by arm, typically
ACTARM.
Functions
lbt14_2_main(): Main TLG functionlbt14_2_lyt(): Layoutlbt14_2_pre(): Preprocessinglbt14_2_check(): Checkslbt14_2_post(): Postprocessing
Note
adam_dbobject must contain anadlbtable with columns"USUBJID","PARAM","BTOXGR","ATOXGR", and the column specified byarm_var.
Examples
run(lbt14_2, syn_data)
#> LBT14 - High Direction
#>
#>
#> ——————————————————————————————————————————————————————————————————————————————————————
#> Parameter
#> Baseline NCI-CTCAE Grade A: Drug X B: Placebo C: Combination
#> Post-baseline NCI-CTCAE Grade (N=134) (N=134) (N=132)
#> ——————————————————————————————————————————————————————————————————————————————————————
#> Alanine Aminotransferase Measurement
#> Not High 121 118 118
#> Not High 72 (59.5%) 70 (59.3%) 59 (50.0%)
#> 1 16 (13.2%) 13 (11.0%) 17 (14.4%)
#> 2 13 (10.7%) 12 (10.2%) 18 (15.3%)
#> 3 9 (7.4%) 14 (11.9%) 12 (10.2%)
#> 4 11 (9.1%) 9 (7.6%) 12 (10.2%)
#> 1 4 4 3
#> Not High 1 (25.0%) 1 (25.0%) 2 (66.7%)
#> 1 1 (25.0%) 0 0
#> 2 1 (25.0%) 0 0
#> 3 0 1 (25.0%) 1 (33.3%)
#> 4 1 (25.0%) 2 (50.0%) 0
#> 2 4 4 4
#> Not High 3 (75.0%) 3 (75.0%) 3 (75.0%)
#> 1 0 1 (25.0%) 1 (25.0%)
#> 2 1 (25.0%) 0 0
#> 3 2 5 5
#> Not High 2 (100%) 2 (40.0%) 4 (80.0%)
#> 1 0 2 (40.0%) 0
#> 2 0 1 (20.0%) 0
#> 4 0 0 1 (20.0%)
#> 4 3 3 2
#> Not High 1 (33.3%) 2 (66.7%) 2 (100%)
#> 1 1 (33.3%) 0 0
#> 3 1 (33.3%) 1 (33.3%) 0
#> C-Reactive Protein Measurement
#> Not High 115 115 114
#> Not High 60 (52.2%) 68 (59.1%) 70 (61.4%)
#> 1 17 (14.8%) 13 (11.3%) 9 (7.9%)
#> 2 12 (10.4%) 14 (12.2%) 13 (11.4%)
#> 3 16 (13.9%) 10 (8.7%) 13 (11.4%)
#> 4 10 (8.7%) 10 (8.7%) 9 (7.9%)
#> 1 5 5 5
#> Not High 4 (80.0%) 3 (60.0%) 5 (100%)
#> 2 0 2 (40.0%) 0
#> 4 1 (20.0%) 0 0
#> 2 6 5 5
#> Not High 3 (50.0%) 3 (60.0%) 4 (80.0%)
#> 1 0 1 (20.0%) 0
#> 2 2 (33.3%) 0 0
#> 4 1 (16.7%) 1 (20.0%) 1 (20.0%)
#> 3 2 3 5
#> Not High 2 (100%) 1 (33.3%) 4 (80.0%)
#> 3 0 1 (33.3%) 1 (20.0%)
#> 4 0 1 (33.3%) 0
#> 4 6 6 3
#> Not High 5 (83.3%) 4 (66.7%) 3 (100%)
#> 1 0 1 (16.7%) 0
#> 2 1 (16.7%) 0 0
#> 3 0 1 (16.7%) 0
#> Immunoglobulin A Measurement
#> Not High 119 123 119
#> Not High 61 (51.3%) 69 (56.1%) 74 (62.2%)
#> 1 24 (20.2%) 12 (9.8%) 13 (10.9%)
#> 2 13 (10.9%) 20 (16.3%) 12 (10.1%)
#> 3 11 (9.2%) 11 (8.9%) 16 (13.4%)
#> 4 10 (8.4%) 11 (8.9%) 4 (3.4%)
#> 1 2 4 6
#> Not High 2 (100%) 2 (50.0%) 5 (83.3%)
#> 2 0 0 1 (16.7%)
#> 4 0 2 (50.0%) 0
#> 2 4 4 3
#> Not High 3 (75.0%) 2 (50.0%) 1 (33.3%)
#> 1 0 2 (50.0%) 0
#> 2 0 0 1 (33.3%)
#> 3 0 0 1 (33.3%)
#> 4 1 (25.0%) 0 0
#> 3 5 2 2
#> Not High 3 (60.0%) 0 1 (50.0%)
#> 1 1 (20.0%) 0 0
#> 2 0 0 1 (50.0%)
#> 3 1 (20.0%) 2 (100%) 0
#> 4 4 1 2
#> Not High 3 (75.0%) 1 (100%) 1 (50.0%)
#> 2 1 (25.0%) 0 1 (50.0%)