Data input for teal app
cdisc_data.Rd![[Stable]](figures/lifecycle-stable.svg)
Function takes datasets and creates CDISCTealData object which can be used in teal applications.
Arguments
- ...
(
TealDataConnector,TealDatasetorTealDatasetConnector) elements to include whereADSLdata is mandatory.- join_keys
(
JoinKeys) or a single (JoinKeySet)
(optional) object with datasets column names used for joining. If empty then it would be automatically derived basing on intersection of datasets primary keys- code
(
character) code to reproduce the datasets.- check
(
logical) reproducibility check - whether to perform a check that the pre-processing code included in the object definitions actually produces those objects. Ifcheckis true and preprocessing code is empty an error will be thrown.
Note
This function does not automatically assign keys to TealDataset
and TealDatasetConnector objects passed to it. If the keys are needed
they should be assigned before calling cdisc_data. See example:
Examples
library(scda)
ADSL <- synthetic_cdisc_data("latest")$adsl
ADTTE <- synthetic_cdisc_data("latest")$adtte
# basic example
cdisc_data(
cdisc_dataset("ADSL", ADSL),
cdisc_dataset("ADTTE", ADTTE),
code = 'ADSL <- synthetic_cdisc_data("latest")$adsl
ADTTE <- synthetic_cdisc_data("latest")$adtte',
check = TRUE
)
#> A CDISCTealData object containing 2 TealDataset/TealDatasetConnector object(s) as element(s):
#> --> Element 1:
#> A CDISCTealDataset object containing the following data.frame (400 rows and 44 columns):
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX
#> 1 AB12345 AB12345-CHN-3-id-128 id-128 CHN-3 32 YEARS M
#> 2 AB12345 AB12345-CHN-15-id-262 id-262 CHN-15 35 YEARS M
#> 3 AB12345 AB12345-RUS-3-id-378 id-378 RUS-3 30 YEARS F
#> 4 AB12345 AB12345-CHN-11-id-220 id-220 CHN-11 26 YEARS F
#> 5 AB12345 AB12345-CHN-7-id-267 id-267 CHN-7 40 YEARS M
#> 6 AB12345 AB12345-CHN-15-id-201 id-201 CHN-15 49 YEARS M
#> RACE ETHNIC COUNTRY DTHFL INVID
#> 1 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-3
#> 2 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO CHN N INV ID CHN-15
#> 3 ASIAN NOT HISPANIC OR LATINO RUS N INV ID RUS-3
#> 4 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-11
#> 5 ASIAN UNKNOWN CHN N INV ID CHN-7
#> 6 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-15
#> INVNAM ARM ARMCD ACTARM ACTARMCD TRT01P
#> 1 Dr. CHN-3 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X
#> 2 Dr. CHN-15 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> 3 Dr. RUS-3 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> 4 Dr. CHN-11 Doe B: Placebo ARM B B: Placebo ARM B B: Placebo
#> 5 Dr. CHN-7 Doe B: Placebo ARM B B: Placebo ARM B B: Placebo
#> 6 Dr. CHN-15 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> TRT01A REGION1 STRATA1 STRATA2 BMRKR1 BMRKR2 ITTFL SAFFL BMEASIFL
#> 1 A: Drug X Asia C S2 14.424934 MEDIUM Y Y Y
#> 2 C: Combination Asia C S1 4.055463 LOW Y Y N
#> 3 C: Combination Eurasia A S1 2.803240 HIGH Y Y Y
#> 4 B: Placebo Asia B S2 10.262734 MEDIUM Y Y Y
#> 5 B: Placebo Asia C S1 6.206763 LOW Y Y N
#> 6 C: Combination Asia C S2 6.906799 MEDIUM Y Y Y
#> BEP01FL RANDDT TRTSDTM TRTEDTM EOSSTT
#> 1 Y 2019-02-22 2019-02-24 11:09:18 2021-02-23 22:47:42 COMPLETED
#> 2 N 2019-02-26 2019-02-26 09:05:00 2021-02-25 20:43:24 COMPLETED
#> 3 N 2019-02-24 2019-02-28 03:19:08 2021-02-27 14:57:32 COMPLETED
#> 4 Y 2019-02-27 2019-03-01 13:33:03 2021-03-01 01:11:27 COMPLETED
#> 5 N 2019-03-01 2019-03-02 00:09:16 2021-03-01 11:47:40 COMPLETED
#> 6 N 2019-03-05 2019-03-05 15:23:44 2021-02-17 20:24:57 DISCONTINUED
#> EOTSTT EOSDT EOSDY DCSREAS DTHDT DTHCAUS DTHCAT LDDTHELD
#> 1 COMPLETED 2021-02-23 731 <NA> <NA> <NA> <NA> NA
#> 2 COMPLETED 2021-02-25 731 <NA> <NA> <NA> <NA> NA
#> 3 COMPLETED 2021-02-27 731 <NA> <NA> <NA> <NA> NA
#> 4 COMPLETED 2021-03-01 731 <NA> <NA> <NA> <NA> NA
#> 5 COMPLETED 2021-03-01 731 <NA> <NA> <NA> <NA> NA
#> 6 DISCONTINUED 2021-02-17 716 LACK OF EFFICACY <NA> <NA> <NA> NA
#> LDDTHGR1 LSTALVDT DTHADY study_duration_secs
#> 1 <NA> 2021-03-05 NA 63113904
#> 2 <NA> 2021-03-15 NA 63113904
#> 3 <NA> 2021-03-15 NA 63113904
#> 4 <NA> 2021-03-17 NA 63113904
#> 5 <NA> 2021-03-25 NA 63113904
#> 6 <NA> 2021-03-01 NA 63113904
#>
#> ...
#> # A tibble: 6 × 44
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-CH… id-11 CHN-9 28 YEARS F NATI… HISPA… CHN N
#> 2 AB12345 AB12345-CH… id-352 CHN-16 28 YEARS M ASIAN HISPA… CHN N
#> 3 AB12345 AB12345-CH… id-186 CHN-1 27 YEARS M ASIAN NOT H… CHN N
#> 4 AB12345 AB12345-CH… id-371 CHN-1 28 YEARS F ASIAN NOT H… CHN Y
#> 5 AB12345 AB12345-CH… id-233 CHN-1 36 YEARS F BLAC… NOT H… CHN N
#> 6 AB12345 AB12345-US… id-131 USA-12 44 YEARS F AMER… NOT H… USA N
#> # … with 33 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, REGION1 <fct>,
#> # STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>, BMRKR2 <fct>, ITTFL <fct>,
#> # SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>, RANDDT <date>, TRTSDTM <dttm>,
#> # TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>, EOSDT <date>, EOSDY <int>,
#> # DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>, DTHCAT <fct>, LDDTHELD <int>,
#> # LDDTHGR1 <fct>, LSTALVDT <date>, DTHADY <int>, study_duration_secs <dbl>
#> --> Element 2:
#> A CDISCTealDataset object containing the following data.frame (1600 rows and 55 columns):
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX
#> 1 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 2 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 3 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 4 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 5 AB12345 AB12345-BRA-1-id-134 id-134 BRA-1 47 YEARS M
#> 6 AB12345 AB12345-BRA-1-id-134 id-134 BRA-1 47 YEARS M
#> RACE ETHNIC COUNTRY DTHFL INVID
#> 1 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 2 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 3 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 4 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 5 WHITE NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 6 WHITE NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> INVNAM ARM ARMCD ACTARM ACTARMCD TRT01P TRT01A
#> 1 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 2 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 3 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 4 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 5 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 6 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> REGION1 STRATA1 STRATA2 BMRKR1 BMRKR2 ITTFL SAFFL BMEASIFL BEP01FL
#> 1 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 2 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 3 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 4 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 5 South America B S2 6.462991 LOW Y Y Y N
#> 6 South America B S2 6.462991 LOW Y Y Y N
#> RANDDT TRTSDTM TRTEDTM EOSSTT EOTSTT
#> 1 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 2 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 3 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 4 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 5 2020-11-03 2020-11-04 03:50:33 2022-11-04 15:28:57 COMPLETED COMPLETED
#> 6 2020-11-03 2020-11-04 03:50:33 2022-11-04 15:28:57 COMPLETED COMPLETED
#> EOSDT EOSDY DCSREAS DTHDT DTHCAUS DTHCAT LDDTHELD LDDTHGR1
#> 1 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 2 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 3 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 4 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 5 2022-11-04 731 <NA> <NA> <NA> <NA> NA <NA>
#> 6 2022-11-04 731 <NA> <NA> <NA> <NA> NA <NA>
#> LSTALVDT DTHADY study_duration_secs ASEQ TTESEQ
#> 1 2021-03-07 NA 63113904 2 2
#> 2 2021-03-07 NA 63113904 4 4
#> 3 2021-03-07 NA 63113904 3 3
#> 4 2021-03-07 NA 63113904 1 1
#> 5 2022-11-15 NA 63113904 4 4
#> 6 2022-11-15 NA 63113904 2 2
#> PARAM PARAMCD AVAL AVALU ADTM ADY CNSR
#> 1 Duration of Confirmed Response CRSD 1273.8498 DAYS 2020-08-13 158 1
#> 2 Event Free Survival EFS 135.9787 DAYS 2021-02-16 345 0
#> 3 Overall Survival OS 1759.8678 DAYS 2020-11-05 242 0
#> 4 Progression Free Survival PFS 241.1912 DAYS 2020-07-23 137 0
#> 5 Duration of Confirmed Response CRSD 544.5728 DAYS 2021-10-25 355 0
#> 6 Event Free Survival EFS 401.2725 DAYS 2021-05-05 182 1
#> EVNTDESC CNSDTDSC
#> 1 Last Date Known To Be Alive End of AE Reporting Period
#> 2 Death
#> 3 Death
#> 4 Disease Progression
#> 5 Death
#> 6 Last Date Known To Be Alive Completion or Discontinuation
#>
#> ...
#> # A tibble: 6 × 55
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-US… id-206 USA-8 34 YEARS F ASIAN NOT H… USA N
#> 2 AB12345 AB12345-US… id-206 USA-8 34 YEARS F ASIAN NOT H… USA N
#> 3 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 4 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 5 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 6 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> # … with 44 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, REGION1 <fct>,
#> # STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>, BMRKR2 <fct>, ITTFL <fct>,
#> # SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>, RANDDT <date>, TRTSDTM <dttm>,
#> # TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>, EOSDT <date>, EOSDY <int>,
#> # DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>, DTHCAT <fct>, LDDTHELD <int>,
#> # LDDTHGR1 <fct>, LSTALVDT <date>, DTHADY <int>, study_duration_secs <dbl>, …
# Example with keys
cdisc_data(
cdisc_dataset("ADSL", ADSL,
keys = c("STUDYID", "USUBJID")
),
cdisc_dataset("ADTTE", ADTTE,
keys = c("STUDYID", "USUBJID", "PARAMCD"),
parent = "ADSL"
),
join_keys = join_keys(
join_key(
"ADSL",
"ADTTE",
c("STUDYID" = "STUDYID", "USUBJID" = "USUBJID")
)
),
code = 'ADSL <- synthetic_cdisc_data("latest")$adsl
ADTTE <- synthetic_cdisc_data("latest")$adtte',
check = TRUE
)
#> A CDISCTealData object containing 2 TealDataset/TealDatasetConnector object(s) as element(s):
#> --> Element 1:
#> A CDISCTealDataset object containing the following data.frame (400 rows and 44 columns):
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX
#> 1 AB12345 AB12345-CHN-3-id-128 id-128 CHN-3 32 YEARS M
#> 2 AB12345 AB12345-CHN-15-id-262 id-262 CHN-15 35 YEARS M
#> 3 AB12345 AB12345-RUS-3-id-378 id-378 RUS-3 30 YEARS F
#> 4 AB12345 AB12345-CHN-11-id-220 id-220 CHN-11 26 YEARS F
#> 5 AB12345 AB12345-CHN-7-id-267 id-267 CHN-7 40 YEARS M
#> 6 AB12345 AB12345-CHN-15-id-201 id-201 CHN-15 49 YEARS M
#> RACE ETHNIC COUNTRY DTHFL INVID
#> 1 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-3
#> 2 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO CHN N INV ID CHN-15
#> 3 ASIAN NOT HISPANIC OR LATINO RUS N INV ID RUS-3
#> 4 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-11
#> 5 ASIAN UNKNOWN CHN N INV ID CHN-7
#> 6 ASIAN NOT HISPANIC OR LATINO CHN N INV ID CHN-15
#> INVNAM ARM ARMCD ACTARM ACTARMCD TRT01P
#> 1 Dr. CHN-3 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X
#> 2 Dr. CHN-15 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> 3 Dr. RUS-3 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> 4 Dr. CHN-11 Doe B: Placebo ARM B B: Placebo ARM B B: Placebo
#> 5 Dr. CHN-7 Doe B: Placebo ARM B B: Placebo ARM B B: Placebo
#> 6 Dr. CHN-15 Doe C: Combination ARM C C: Combination ARM C C: Combination
#> TRT01A REGION1 STRATA1 STRATA2 BMRKR1 BMRKR2 ITTFL SAFFL BMEASIFL
#> 1 A: Drug X Asia C S2 14.424934 MEDIUM Y Y Y
#> 2 C: Combination Asia C S1 4.055463 LOW Y Y N
#> 3 C: Combination Eurasia A S1 2.803240 HIGH Y Y Y
#> 4 B: Placebo Asia B S2 10.262734 MEDIUM Y Y Y
#> 5 B: Placebo Asia C S1 6.206763 LOW Y Y N
#> 6 C: Combination Asia C S2 6.906799 MEDIUM Y Y Y
#> BEP01FL RANDDT TRTSDTM TRTEDTM EOSSTT
#> 1 Y 2019-02-22 2019-02-24 11:09:18 2021-02-23 22:47:42 COMPLETED
#> 2 N 2019-02-26 2019-02-26 09:05:00 2021-02-25 20:43:24 COMPLETED
#> 3 N 2019-02-24 2019-02-28 03:19:08 2021-02-27 14:57:32 COMPLETED
#> 4 Y 2019-02-27 2019-03-01 13:33:03 2021-03-01 01:11:27 COMPLETED
#> 5 N 2019-03-01 2019-03-02 00:09:16 2021-03-01 11:47:40 COMPLETED
#> 6 N 2019-03-05 2019-03-05 15:23:44 2021-02-17 20:24:57 DISCONTINUED
#> EOTSTT EOSDT EOSDY DCSREAS DTHDT DTHCAUS DTHCAT LDDTHELD
#> 1 COMPLETED 2021-02-23 731 <NA> <NA> <NA> <NA> NA
#> 2 COMPLETED 2021-02-25 731 <NA> <NA> <NA> <NA> NA
#> 3 COMPLETED 2021-02-27 731 <NA> <NA> <NA> <NA> NA
#> 4 COMPLETED 2021-03-01 731 <NA> <NA> <NA> <NA> NA
#> 5 COMPLETED 2021-03-01 731 <NA> <NA> <NA> <NA> NA
#> 6 DISCONTINUED 2021-02-17 716 LACK OF EFFICACY <NA> <NA> <NA> NA
#> LDDTHGR1 LSTALVDT DTHADY study_duration_secs
#> 1 <NA> 2021-03-05 NA 63113904
#> 2 <NA> 2021-03-15 NA 63113904
#> 3 <NA> 2021-03-15 NA 63113904
#> 4 <NA> 2021-03-17 NA 63113904
#> 5 <NA> 2021-03-25 NA 63113904
#> 6 <NA> 2021-03-01 NA 63113904
#>
#> ...
#> # A tibble: 6 × 44
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-CH… id-11 CHN-9 28 YEARS F NATI… HISPA… CHN N
#> 2 AB12345 AB12345-CH… id-352 CHN-16 28 YEARS M ASIAN HISPA… CHN N
#> 3 AB12345 AB12345-CH… id-186 CHN-1 27 YEARS M ASIAN NOT H… CHN N
#> 4 AB12345 AB12345-CH… id-371 CHN-1 28 YEARS F ASIAN NOT H… CHN Y
#> 5 AB12345 AB12345-CH… id-233 CHN-1 36 YEARS F BLAC… NOT H… CHN N
#> 6 AB12345 AB12345-US… id-131 USA-12 44 YEARS F AMER… NOT H… USA N
#> # … with 33 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, REGION1 <fct>,
#> # STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>, BMRKR2 <fct>, ITTFL <fct>,
#> # SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>, RANDDT <date>, TRTSDTM <dttm>,
#> # TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>, EOSDT <date>, EOSDY <int>,
#> # DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>, DTHCAT <fct>, LDDTHELD <int>,
#> # LDDTHGR1 <fct>, LSTALVDT <date>, DTHADY <int>, study_duration_secs <dbl>
#> --> Element 2:
#> A CDISCTealDataset object containing the following data.frame (1600 rows and 55 columns):
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX
#> 1 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 2 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 3 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 4 AB12345 AB12345-BRA-1-id-105 id-105 BRA-1 38 YEARS M
#> 5 AB12345 AB12345-BRA-1-id-134 id-134 BRA-1 47 YEARS M
#> 6 AB12345 AB12345-BRA-1-id-134 id-134 BRA-1 47 YEARS M
#> RACE ETHNIC COUNTRY DTHFL INVID
#> 1 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 2 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 3 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 4 BLACK OR AFRICAN AMERICAN NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 5 WHITE NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> 6 WHITE NOT HISPANIC OR LATINO BRA N INV ID BRA-1
#> INVNAM ARM ARMCD ACTARM ACTARMCD TRT01P TRT01A
#> 1 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 2 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 3 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 4 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 5 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> 6 Dr. BRA-1 Doe A: Drug X ARM A A: Drug X ARM A A: Drug X A: Drug X
#> REGION1 STRATA1 STRATA2 BMRKR1 BMRKR2 ITTFL SAFFL BMEASIFL BEP01FL
#> 1 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 2 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 3 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 4 South America B S1 4.156914 MEDIUM Y Y Y Y
#> 5 South America B S2 6.462991 LOW Y Y Y N
#> 6 South America B S2 6.462991 LOW Y Y Y N
#> RANDDT TRTSDTM TRTEDTM EOSSTT EOTSTT
#> 1 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 2 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 3 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 4 2020-03-08 2020-03-08 05:28:11 2021-02-17 18:49:59 DISCONTINUED DISCONTINUED
#> 5 2020-11-03 2020-11-04 03:50:33 2022-11-04 15:28:57 COMPLETED COMPLETED
#> 6 2020-11-03 2020-11-04 03:50:33 2022-11-04 15:28:57 COMPLETED COMPLETED
#> EOSDT EOSDY DCSREAS DTHDT DTHCAUS DTHCAT LDDTHELD LDDTHGR1
#> 1 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 2 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 3 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 4 2021-02-17 347 ADVERSE EVENT <NA> <NA> <NA> NA <NA>
#> 5 2022-11-04 731 <NA> <NA> <NA> <NA> NA <NA>
#> 6 2022-11-04 731 <NA> <NA> <NA> <NA> NA <NA>
#> LSTALVDT DTHADY study_duration_secs ASEQ TTESEQ
#> 1 2021-03-07 NA 63113904 2 2
#> 2 2021-03-07 NA 63113904 4 4
#> 3 2021-03-07 NA 63113904 3 3
#> 4 2021-03-07 NA 63113904 1 1
#> 5 2022-11-15 NA 63113904 4 4
#> 6 2022-11-15 NA 63113904 2 2
#> PARAM PARAMCD AVAL AVALU ADTM ADY CNSR
#> 1 Duration of Confirmed Response CRSD 1273.8498 DAYS 2020-08-13 158 1
#> 2 Event Free Survival EFS 135.9787 DAYS 2021-02-16 345 0
#> 3 Overall Survival OS 1759.8678 DAYS 2020-11-05 242 0
#> 4 Progression Free Survival PFS 241.1912 DAYS 2020-07-23 137 0
#> 5 Duration of Confirmed Response CRSD 544.5728 DAYS 2021-10-25 355 0
#> 6 Event Free Survival EFS 401.2725 DAYS 2021-05-05 182 1
#> EVNTDESC CNSDTDSC
#> 1 Last Date Known To Be Alive End of AE Reporting Period
#> 2 Death
#> 3 Death
#> 4 Disease Progression
#> 5 Death
#> 6 Last Date Known To Be Alive Completion or Discontinuation
#>
#> ...
#> # A tibble: 6 × 55
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-US… id-206 USA-8 34 YEARS F ASIAN NOT H… USA N
#> 2 AB12345 AB12345-US… id-206 USA-8 34 YEARS F ASIAN NOT H… USA N
#> 3 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 4 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 5 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> 6 AB12345 AB12345-US… id-130 USA-9 40 YEARS M ASIAN NOT H… USA N
#> # … with 44 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, REGION1 <fct>,
#> # STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>, BMRKR2 <fct>, ITTFL <fct>,
#> # SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>, RANDDT <date>, TRTSDTM <dttm>,
#> # TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>, EOSDT <date>, EOSDY <int>,
#> # DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>, DTHCAT <fct>, LDDTHELD <int>,
#> # LDDTHGR1 <fct>, LSTALVDT <date>, DTHADY <int>, study_duration_secs <dbl>, …