This function creates a data set with a single simulated oncology clinical trial with one row per transition based on an illness-death model. Studies with an arbitrary number of treatment arms are possible.
(integer)
numbers of patients per treatment arm.
(list)
transition parameters for each treatment group.
See exponential_transition(), piecewise_exponential() and weibull_transition() for details.
dropout (list)
specifies drop-out probability. See getSimulatedData() for details.
Can be specified either as one list that should be applied to all treatment groups or a separate list
for each treatment group.
accrual (list)
specifies accrual intensity. See addStaggeredEntry() for details.
Can be specified either as one list that should be applied to all treatment groups or a separate list
for each treatment group.
This returns a data frame with one simulated clinical trial and multiple treatment arms.
See getSimulatedData() for the explanation of the columns. The column trt contains the treatment indicator.
This is a helper function of getClinicalTrials().
transition1 <- exponential_transition(h01 = 1.2, h02 = 1.5, h12 = 1.6)
transition2 <- exponential_transition(h01 = 1, h02 = 1.3, h12 = 1.7)
transition3 <- exponential_transition(h01 = 1.1, h02 = 1, h12 = 1.5)
getOneClinicalTrial(
nPat = c(30, 20, 30), transitionByArm = list(transition1, transition2, transition3),
dropout = list(rate = 0, time = 12),
accrual = list(param = "time", value = 0)
)
#> id from to entry exit entryAct exitAct censAct trt
#> 1 1 0 2 0.000000000 0.963673284 0.000000000 0.963673284 Inf 1
#> 2 2 0 1 0.000000000 1.041846534 0.000000000 1.041846534 Inf 1
#> 3 2 1 2 1.041846534 1.586905060 1.041846534 1.586905060 Inf 1
#> 4 3 0 2 0.000000000 0.477939717 0.000000000 0.477939717 Inf 1
#> 5 4 0 2 0.000000000 0.198632402 0.000000000 0.198632402 Inf 1
#> 6 5 0 1 0.000000000 0.836504820 0.000000000 0.836504820 Inf 1
#> 7 5 1 2 0.836504820 1.580203688 0.836504820 1.580203688 Inf 1
#> 8 6 0 1 0.000000000 0.144586256 0.000000000 0.144586256 Inf 1
#> 9 6 1 2 0.144586256 0.983362551 0.144586256 0.983362551 Inf 1
#> 10 7 0 2 0.000000000 0.738316279 0.000000000 0.738316279 Inf 1
#> 11 8 0 1 0.000000000 0.324248942 0.000000000 0.324248942 Inf 1
#> 12 8 1 2 0.324248942 0.556819050 0.324248942 0.556819050 Inf 1
#> 13 9 0 1 0.000000000 0.120698069 0.000000000 0.120698069 Inf 1
#> 14 9 1 2 0.120698069 0.381017745 0.120698069 0.381017745 Inf 1
#> 15 10 0 1 0.000000000 0.379847986 0.000000000 0.379847986 Inf 1
#> 16 10 1 2 0.379847986 0.498251214 0.379847986 0.498251214 Inf 1
#> 17 11 0 1 0.000000000 0.550436302 0.000000000 0.550436302 Inf 1
#> 18 11 1 2 0.550436302 2.475427652 0.550436302 2.475427652 Inf 1
#> 19 12 0 1 0.000000000 0.065405460 0.000000000 0.065405460 Inf 1
#> 20 12 1 2 0.065405460 0.469864524 0.065405460 0.469864524 Inf 1
#> 21 13 0 1 0.000000000 0.416168752 0.000000000 0.416168752 Inf 1
#> 22 13 1 2 0.416168752 0.783483951 0.416168752 0.783483951 Inf 1
#> 23 14 0 1 0.000000000 0.848635343 0.000000000 0.848635343 Inf 1
#> 24 14 1 2 0.848635343 0.858052889 0.848635343 0.858052889 Inf 1
#> 25 15 0 2 0.000000000 0.293636775 0.000000000 0.293636775 Inf 1
#> 26 16 0 1 0.000000000 0.190591749 0.000000000 0.190591749 Inf 1
#> 27 16 1 2 0.190591749 0.687177090 0.190591749 0.687177090 Inf 1
#> 28 17 0 2 0.000000000 0.074930422 0.000000000 0.074930422 Inf 1
#> 29 18 0 2 0.000000000 0.799729649 0.000000000 0.799729649 Inf 1
#> 30 19 0 1 0.000000000 0.473761520 0.000000000 0.473761520 Inf 1
#> 31 19 1 2 0.473761520 0.693197582 0.473761520 0.693197582 Inf 1
#> 32 20 0 2 0.000000000 0.623404745 0.000000000 0.623404745 Inf 1
#> 33 21 0 1 0.000000000 0.276036099 0.000000000 0.276036099 Inf 1
#> 34 21 1 2 0.276036099 0.658747871 0.276036099 0.658747871 Inf 1
#> 35 22 0 2 0.000000000 0.248112642 0.000000000 0.248112642 Inf 1
#> 36 23 0 2 0.000000000 0.166077237 0.000000000 0.166077237 Inf 1
#> 37 24 0 2 0.000000000 0.119202878 0.000000000 0.119202878 Inf 1
#> 38 25 0 1 0.000000000 0.638967936 0.000000000 0.638967936 Inf 1
#> 39 25 1 2 0.638967936 0.741310222 0.638967936 0.741310222 Inf 1
#> 40 26 0 1 0.000000000 0.485001721 0.000000000 0.485001721 Inf 1
#> 41 26 1 2 0.485001721 1.495003407 0.485001721 1.495003407 Inf 1
#> 42 27 0 2 0.000000000 0.677533459 0.000000000 0.677533459 Inf 1
#> 43 28 0 2 0.000000000 0.424758013 0.000000000 0.424758013 Inf 1
#> 44 29 0 1 0.000000000 0.612796632 0.000000000 0.612796632 Inf 1
#> 45 29 1 2 0.612796632 1.552896927 0.612796632 1.552896927 Inf 1
#> 46 30 0 2 0.000000000 0.063063325 0.000000000 0.063063325 Inf 1
#> 47 31 0 1 0.000000000 0.108645977 0.000000000 0.108645977 Inf 2
#> 48 31 1 2 0.108645977 0.540585216 0.108645977 0.540585216 Inf 2
#> 49 32 0 2 0.000000000 0.008677608 0.000000000 0.008677608 Inf 2
#> 50 33 0 2 0.000000000 0.376999758 0.000000000 0.376999758 Inf 2
#> 51 34 0 1 0.000000000 0.004662485 0.000000000 0.004662485 Inf 2
#> 52 34 1 2 0.004662485 0.390248633 0.004662485 0.390248633 Inf 2
#> 53 35 0 2 0.000000000 0.549150618 0.000000000 0.549150618 Inf 2
#> 54 36 0 2 0.000000000 0.252850824 0.000000000 0.252850824 Inf 2
#> 55 37 0 2 0.000000000 0.048971014 0.000000000 0.048971014 Inf 2
#> 56 38 0 2 0.000000000 1.190994143 0.000000000 1.190994143 Inf 2
#> 57 39 0 1 0.000000000 0.387723021 0.000000000 0.387723021 Inf 2
#> 58 39 1 2 0.387723021 3.069441651 0.387723021 3.069441651 Inf 2
#> 59 40 0 2 0.000000000 0.153998393 0.000000000 0.153998393 Inf 2
#> 60 41 0 2 0.000000000 0.140612650 0.000000000 0.140612650 Inf 2
#> 61 42 0 2 0.000000000 0.115334711 0.000000000 0.115334711 Inf 2
#> 62 43 0 2 0.000000000 1.117426714 0.000000000 1.117426714 Inf 2
#> 63 44 0 2 0.000000000 0.369076069 0.000000000 0.369076069 Inf 2
#> 64 45 0 1 0.000000000 0.619694733 0.000000000 0.619694733 Inf 2
#> 65 45 1 2 0.619694733 1.909350201 0.619694733 1.909350201 Inf 2
#> 66 46 0 2 0.000000000 0.069418866 0.000000000 0.069418866 Inf 2
#> 67 47 0 2 0.000000000 0.018769671 0.000000000 0.018769671 Inf 2
#> 68 48 0 2 0.000000000 0.180340436 0.000000000 0.180340436 Inf 2
#> 69 49 0 1 0.000000000 0.748051530 0.000000000 0.748051530 Inf 2
#> 70 49 1 2 0.748051530 0.875678484 0.748051530 0.875678484 Inf 2
#> 71 50 0 2 0.000000000 1.073077454 0.000000000 1.073077454 Inf 2
#> 72 51 0 1 0.000000000 0.063585154 0.000000000 0.063585154 Inf 3
#> 73 51 1 2 0.063585154 0.169398825 0.063585154 0.169398825 Inf 3
#> 74 52 0 2 0.000000000 1.324966440 0.000000000 1.324966440 Inf 3
#> 75 53 0 1 0.000000000 0.227653135 0.000000000 0.227653135 Inf 3
#> 76 53 1 2 0.227653135 0.640835097 0.227653135 0.640835097 Inf 3
#> 77 54 0 1 0.000000000 0.026038723 0.000000000 0.026038723 Inf 3
#> 78 54 1 2 0.026038723 0.636689636 0.026038723 0.636689636 Inf 3
#> 79 55 0 2 0.000000000 0.155402816 0.000000000 0.155402816 Inf 3
#> 80 56 0 1 0.000000000 0.072191253 0.000000000 0.072191253 Inf 3
#> 81 56 1 2 0.072191253 0.556745505 0.072191253 0.556745505 Inf 3
#> 82 57 0 1 0.000000000 0.727734457 0.000000000 0.727734457 Inf 3
#> 83 57 1 2 0.727734457 1.128613158 0.727734457 1.128613158 Inf 3
#> 84 58 0 2 0.000000000 0.096652997 0.000000000 0.096652997 Inf 3
#> 85 59 0 2 0.000000000 1.041313011 0.000000000 1.041313011 Inf 3
#> 86 60 0 1 0.000000000 0.031554070 0.000000000 0.031554070 Inf 3
#> 87 60 1 2 0.031554070 0.378476550 0.031554070 0.378476550 Inf 3
#> 88 61 0 2 0.000000000 1.049345811 0.000000000 1.049345811 Inf 3
#> 89 62 0 2 0.000000000 1.274462026 0.000000000 1.274462026 Inf 3
#> 90 63 0 1 0.000000000 0.262239182 0.000000000 0.262239182 Inf 3
#> 91 63 1 2 0.262239182 1.185368013 0.262239182 1.185368013 Inf 3
#> 92 64 0 2 0.000000000 0.901371136 0.000000000 0.901371136 Inf 3
#> 93 65 0 2 0.000000000 0.009099860 0.000000000 0.009099860 Inf 3
#> 94 66 0 2 0.000000000 1.173042134 0.000000000 1.173042134 Inf 3
#> 95 67 0 2 0.000000000 0.218041763 0.000000000 0.218041763 Inf 3
#> 96 68 0 2 0.000000000 0.150703354 0.000000000 0.150703354 Inf 3
#> 97 69 0 2 0.000000000 0.176833163 0.000000000 0.176833163 Inf 3
#> 98 70 0 2 0.000000000 0.363713581 0.000000000 0.363713581 Inf 3
#> 99 71 0 2 0.000000000 0.290230965 0.000000000 0.290230965 Inf 3
#> 100 72 0 2 0.000000000 0.965436826 0.000000000 0.965436826 Inf 3
#> 101 73 0 2 0.000000000 1.290563037 0.000000000 1.290563037 Inf 3
#> 102 74 0 1 0.000000000 0.921337732 0.000000000 0.921337732 Inf 3
#> 103 74 1 2 0.921337732 1.411323176 0.921337732 1.411323176 Inf 3
#> 104 75 0 1 0.000000000 0.370194057 0.000000000 0.370194057 Inf 3
#> 105 75 1 2 0.370194057 0.998483516 0.370194057 0.998483516 Inf 3
#> 106 76 0 2 0.000000000 0.593267184 0.000000000 0.593267184 Inf 3
#> 107 77 0 2 0.000000000 0.087529620 0.000000000 0.087529620 Inf 3
#> 108 78 0 2 0.000000000 0.394015487 0.000000000 0.394015487 Inf 3
#> 109 79 0 1 0.000000000 0.473727459 0.000000000 0.473727459 Inf 3
#> 110 79 1 2 0.473727459 0.489373740 0.473727459 0.489373740 Inf 3
#> 111 80 0 1 0.000000000 0.062052474 0.000000000 0.062052474 Inf 3
#> 112 80 1 2 0.062052474 0.130825736 0.062052474 0.130825736 Inf 3