R/getClinicalTrials.R
getOneClinicalTrial.RdThis function creates a data set with a single simulated oncology clinical trial with one row per transition based on an illness-death model. Studies with an arbitrary number of treatment arms are possible.
(integer)
numbers of patients per treatment arm.
(list)
transition parameters for each treatment group.
See exponential_transition(), piecewise_exponential() and weibull_transition() for details.
dropout (list)
specifies drop-out probability. See getSimulatedData() for details.
accrual (list)
specifies accrual intensity. See addStaggeredEntry() for details.
This returns a data frame with one simulated clinical trial and multiple treatment arms.
See getSimulatedData() for the explanation of the columns. The column trt contains the treatment indicator.
This is a helper function of getClinicalTrials().
transition1 <- exponential_transition(h01 = 1.2, h02 = 1.5, h12 = 1.6)
transition2 <- exponential_transition(h01 = 1, h02 = 1.3, h12 = 1.7)
transition3 <- exponential_transition(h01 = 1.1, h02 = 1, h12 = 1.5)
getOneClinicalTrial(
nPat = c(30, 20, 30), transitionByArm = list(transition1, transition2, transition3),
dropout = list(rate = 0, time = 12),
accrual = list(param = "time", value = 0)
)
#> id from to entry exit entryAct exitAct censAct trt
#> 1 1 0 1 0.000000000 0.148022934 0.000000000 0.148022934 Inf 1
#> 2 1 1 2 0.148022934 1.333998383 0.148022934 1.333998383 Inf 1
#> 3 2 0 1 0.000000000 0.209486852 0.000000000 0.209486852 Inf 1
#> 4 2 1 2 0.209486852 0.360519213 0.209486852 0.360519213 Inf 1
#> 5 3 0 2 0.000000000 0.015768900 0.000000000 0.015768900 Inf 1
#> 6 4 0 1 0.000000000 0.506287506 0.000000000 0.506287506 Inf 1
#> 7 4 1 2 0.506287506 0.680540891 0.506287506 0.680540891 Inf 1
#> 8 5 0 2 0.000000000 0.629989023 0.000000000 0.629989023 Inf 1
#> 9 6 0 2 0.000000000 0.070282816 0.000000000 0.070282816 Inf 1
#> 10 7 0 2 0.000000000 0.082747110 0.000000000 0.082747110 Inf 1
#> 11 8 0 2 0.000000000 0.105141789 0.000000000 0.105141789 Inf 1
#> 12 9 0 1 0.000000000 0.389225836 0.000000000 0.389225836 Inf 1
#> 13 9 1 2 0.389225836 0.631348129 0.389225836 0.631348129 Inf 1
#> 14 10 0 1 0.000000000 0.580319351 0.000000000 0.580319351 Inf 1
#> 15 10 1 2 0.580319351 1.087102045 0.580319351 1.087102045 Inf 1
#> 16 11 0 1 0.000000000 0.399545952 0.000000000 0.399545952 Inf 1
#> 17 11 1 2 0.399545952 1.003346889 0.399545952 1.003346889 Inf 1
#> 18 12 0 2 0.000000000 0.662607743 0.000000000 0.662607743 Inf 1
#> 19 13 0 1 0.000000000 1.017544441 0.000000000 1.017544441 Inf 1
#> 20 13 1 2 1.017544441 2.605636085 1.017544441 2.605636085 Inf 1
#> 21 14 0 2 0.000000000 0.111087196 0.000000000 0.111087196 Inf 1
#> 22 15 0 2 0.000000000 0.319463058 0.000000000 0.319463058 Inf 1
#> 23 16 0 1 0.000000000 0.786816953 0.000000000 0.786816953 Inf 1
#> 24 16 1 2 0.786816953 1.521027363 0.786816953 1.521027363 Inf 1
#> 25 17 0 1 0.000000000 0.509273180 0.000000000 0.509273180 Inf 1
#> 26 17 1 2 0.509273180 1.833865772 0.509273180 1.833865772 Inf 1
#> 27 18 0 2 0.000000000 0.110217482 0.000000000 0.110217482 Inf 1
#> 28 19 0 2 0.000000000 0.764226012 0.000000000 0.764226012 Inf 1
#> 29 20 0 2 0.000000000 0.504216117 0.000000000 0.504216117 Inf 1
#> 30 21 0 2 0.000000000 0.155148858 0.000000000 0.155148858 Inf 1
#> 31 22 0 1 0.000000000 0.224500273 0.000000000 0.224500273 Inf 1
#> 32 22 1 2 0.224500273 0.704834333 0.224500273 0.704834333 Inf 1
#> 33 23 0 1 0.000000000 0.018570994 0.000000000 0.018570994 Inf 1
#> 34 23 1 2 0.018570994 0.054925605 0.018570994 0.054925605 Inf 1
#> 35 24 0 1 0.000000000 0.517033473 0.000000000 0.517033473 Inf 1
#> 36 24 1 2 0.517033473 0.694284429 0.517033473 0.694284429 Inf 1
#> 37 25 0 2 0.000000000 0.301405817 0.000000000 0.301405817 Inf 1
#> 38 26 0 2 0.000000000 0.389061295 0.000000000 0.389061295 Inf 1
#> 39 27 0 1 0.000000000 0.881948118 0.000000000 0.881948118 Inf 1
#> 40 27 1 2 0.881948118 1.982239477 0.881948118 1.982239477 Inf 1
#> 41 28 0 2 0.000000000 1.180287762 0.000000000 1.180287762 Inf 1
#> 42 29 0 1 0.000000000 0.030809960 0.000000000 0.030809960 Inf 1
#> 43 29 1 2 0.030809960 3.656823105 0.030809960 3.656823105 Inf 1
#> 44 30 0 2 0.000000000 0.280155202 0.000000000 0.280155202 Inf 1
#> 45 31 0 2 0.000000000 0.198637324 0.000000000 0.198637324 Inf 2
#> 46 32 0 2 0.000000000 0.211672056 0.000000000 0.211672056 Inf 2
#> 47 33 0 1 0.000000000 0.134375833 0.000000000 0.134375833 Inf 2
#> 48 33 1 2 0.134375833 1.429174705 0.134375833 1.429174705 Inf 2
#> 49 34 0 2 0.000000000 0.285518514 0.000000000 0.285518514 Inf 2
#> 50 35 0 1 0.000000000 0.063257958 0.000000000 0.063257958 Inf 2
#> 51 35 1 2 0.063257958 0.103876671 0.063257958 0.103876671 Inf 2
#> 52 36 0 2 0.000000000 1.835814756 0.000000000 1.835814756 Inf 2
#> 53 37 0 1 0.000000000 0.206160463 0.000000000 0.206160463 Inf 2
#> 54 37 1 2 0.206160463 0.210416211 0.206160463 0.210416211 Inf 2
#> 55 38 0 2 0.000000000 1.278530643 0.000000000 1.278530643 Inf 2
#> 56 39 0 1 0.000000000 0.610599127 0.000000000 0.610599127 Inf 2
#> 57 39 1 2 0.610599127 0.664125939 0.610599127 0.664125939 Inf 2
#> 58 40 0 2 0.000000000 0.050719057 0.000000000 0.050719057 Inf 2
#> 59 41 0 2 0.000000000 1.122710967 0.000000000 1.122710967 Inf 2
#> 60 42 0 2 0.000000000 1.349863336 0.000000000 1.349863336 Inf 2
#> 61 43 0 2 0.000000000 0.352268028 0.000000000 0.352268028 Inf 2
#> 62 44 0 1 0.000000000 0.134767094 0.000000000 0.134767094 Inf 2
#> 63 44 1 2 0.134767094 1.014544121 0.134767094 1.014544121 Inf 2
#> 64 45 0 2 0.000000000 0.276758356 0.000000000 0.276758356 Inf 2
#> 65 46 0 1 0.000000000 0.039259413 0.000000000 0.039259413 Inf 2
#> 66 46 1 2 0.039259413 0.189337620 0.039259413 0.189337620 Inf 2
#> 67 47 0 2 0.000000000 0.236708277 0.000000000 0.236708277 Inf 2
#> 68 48 0 2 0.000000000 0.115775823 0.000000000 0.115775823 Inf 2
#> 69 49 0 2 0.000000000 0.770179214 0.000000000 0.770179214 Inf 2
#> 70 50 0 1 0.000000000 1.325192268 0.000000000 1.325192268 Inf 2
#> 71 50 1 2 1.325192268 1.645315584 1.325192268 1.645315584 Inf 2
#> 72 51 0 1 0.000000000 0.525947083 0.000000000 0.525947083 Inf 3
#> 73 51 1 2 0.525947083 0.598273885 0.525947083 0.598273885 Inf 3
#> 74 52 0 2 0.000000000 0.118868937 0.000000000 0.118868937 Inf 3
#> 75 53 0 2 0.000000000 0.012552279 0.000000000 0.012552279 Inf 3
#> 76 54 0 1 0.000000000 0.719614118 0.000000000 0.719614118 Inf 3
#> 77 54 1 2 0.719614118 2.454226029 0.719614118 2.454226029 Inf 3
#> 78 55 0 2 0.000000000 0.159367334 0.000000000 0.159367334 Inf 3
#> 79 56 0 2 0.000000000 0.644462194 0.000000000 0.644462194 Inf 3
#> 80 57 0 2 0.000000000 1.953800925 0.000000000 1.953800925 Inf 3
#> 81 58 0 2 0.000000000 0.368045876 0.000000000 0.368045876 Inf 3
#> 82 59 0 2 0.000000000 0.265631665 0.000000000 0.265631665 Inf 3
#> 83 60 0 2 0.000000000 0.093850242 0.000000000 0.093850242 Inf 3
#> 84 61 0 1 0.000000000 0.029088501 0.000000000 0.029088501 Inf 3
#> 85 61 1 2 0.029088501 1.904412262 0.029088501 1.904412262 Inf 3
#> 86 62 0 2 0.000000000 0.130965078 0.000000000 0.130965078 Inf 3
#> 87 63 0 1 0.000000000 0.480749729 0.000000000 0.480749729 Inf 3
#> 88 63 1 2 0.480749729 1.341041219 0.480749729 1.341041219 Inf 3
#> 89 64 0 2 0.000000000 0.025888217 0.000000000 0.025888217 Inf 3
#> 90 65 0 2 0.000000000 0.093122622 0.000000000 0.093122622 Inf 3
#> 91 66 0 2 0.000000000 1.669897838 0.000000000 1.669897838 Inf 3
#> 92 67 0 2 0.000000000 0.028917710 0.000000000 0.028917710 Inf 3
#> 93 68 0 1 0.000000000 0.274555866 0.000000000 0.274555866 Inf 3
#> 94 68 1 2 0.274555866 0.632094191 0.274555866 0.632094191 Inf 3
#> 95 69 0 1 0.000000000 0.975858364 0.000000000 0.975858364 Inf 3
#> 96 69 1 2 0.975858364 2.481567041 0.975858364 2.481567041 Inf 3
#> 97 70 0 1 0.000000000 0.121543429 0.000000000 0.121543429 Inf 3
#> 98 70 1 2 0.121543429 0.381798691 0.121543429 0.381798691 Inf 3
#> 99 71 0 1 0.000000000 0.752356562 0.000000000 0.752356562 Inf 3
#> 100 71 1 2 0.752356562 2.081325865 0.752356562 2.081325865 Inf 3
#> 101 72 0 1 0.000000000 0.007365966 0.000000000 0.007365966 Inf 3
#> 102 72 1 2 0.007365966 0.591014062 0.007365966 0.591014062 Inf 3
#> 103 73 0 2 0.000000000 1.083358976 0.000000000 1.083358976 Inf 3
#> 104 74 0 1 0.000000000 0.193407522 0.000000000 0.193407522 Inf 3
#> 105 74 1 2 0.193407522 0.410664046 0.193407522 0.410664046 Inf 3
#> 106 75 0 2 0.000000000 0.484782232 0.000000000 0.484782232 Inf 3
#> 107 76 0 2 0.000000000 0.164070060 0.000000000 0.164070060 Inf 3
#> 108 77 0 2 0.000000000 0.036236528 0.000000000 0.036236528 Inf 3
#> 109 78 0 2 0.000000000 0.039918033 0.000000000 0.039918033 Inf 3
#> 110 79 0 1 0.000000000 0.393167939 0.000000000 0.393167939 Inf 3
#> 111 79 1 2 0.393167939 1.076894314 0.393167939 1.076894314 Inf 3
#> 112 80 0 2 0.000000000 2.266786247 0.000000000 2.266786247 Inf 3