Laboratory Data Analysis Dataset (ADLB)
radlb.Rd
Function for generating a random Laboratory Data Analysis Dataset for a given Subject-Level Analysis Dataset.
Usage
radlb(
adsl,
lbcat = c("CHEMISTRY", "CHEMISTRY", "IMMUNOLOGY"),
param = c("Alanine Aminotransferase Measurement", "C-Reactive Protein Measurement",
"Immunoglobulin A Measurement"),
paramcd = c("ALT", "CRP", "IGA"),
paramu = c("U/L", "mg/L", "g/L"),
aval_mean = c(18, 9, 2.9),
visit_format = "WEEK",
n_assessments = 5L,
n_days = 5L,
max_n_lbs = 10L,
lookup = NULL,
seed = NULL,
na_percentage = 0,
na_vars = list(LOQFL = c(NA, 0.1), ABLFL2 = c(1234, 0.1), ABLFL = c(1235, 0.1), BASE2 =
c(NA, 0.1), BASE = c(NA, 0.1), CHG2 = c(1235, 0.1), PCHG2 = c(1235, 0.1), CHG =
c(1234, 0.1), PCHG = c(1234, 0.1)),
cached = FALSE
)
Arguments
- adsl
(
data.frame
)
Subject-Level Analysis Dataset (ADSL).- lbcat
(
character vector
)
LB category values.- param
(
character vector
)
Parameter values.- paramcd
(
character vector
)
Parameter code values.- paramu
(
character vector
)
Parameter unit values.- aval_mean
(
numeric vector
)
Mean values corresponding to each parameter.- visit_format
(
character
)
Type of visit. Options are "WEEK" and "CYCLE".- n_assessments
(
integer
)
Number of weeks or cycles.- n_days
(
integer
)
Number of days in each cycle (only used ifvisit_format
is "CYCLE").- max_n_lbs
(
integer
)
Maximum number of labs per patient. Defaults to 10.- lookup
(
data.frame
)
Additional parameters.- seed
(
numeric
)
Seed to use for reproducible random number generation.- na_percentage
(
proportion
)
Default percentage of values to be replaced byNA
.- na_vars
(
list
)
A named list where the name of each element is a column name ofds
. Each element of this list should be a numeric vector with two elements:seed
(numeric
)
The seed to be used for this element - can beNA
.percentage
(proportion
)
Percentage of elements to be replaced withNA
. IfNA
,na_percentage
is used as a default.
- cached
boolean whether the cached ADLB data
cadlb
should be returned or new data should be generated. If set toTRUE
then the other arguments toradlb
will be ignored.
Details
One record per subject per parameter per analysis visit per analysis date.
Keys: STUDYID
, USUBJID
, PARAMCD
, BASETYPE
, AVISITN
, ATPTN
, DTYPE
, ADTM
, LBSEQ
, ASPID
Examples
library(random.cdisc.data)
adsl <- radsl(N = 10, seed = 1, study_duration = 2)
adlb <- radlb(adsl, visit_format = "WEEK", n_assessments = 7L, seed = 2)
adlb
#> # A tibble: 270 × 102
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 2 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 3 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 4 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 5 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 6 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 7 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 8 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 9 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 10 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> # ℹ 260 more rows
#> # ℹ 91 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, TRT02P <fct>,
#> # TRT02A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> # BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> # AEWITHFL <fct>, RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>,
#> # TRT01SDTM <dttm>, TRT01EDTM <dttm>, TRT02SDTM <dttm>, TRT02EDTM <dttm>, …
adlb <- radlb(adsl, visit_format = "CYCLE", n_assessments = 2L, seed = 2)
adlb
#> # A tibble: 330 × 102
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 2 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 3 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 4 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 5 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 6 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 7 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 8 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 9 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 10 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> # ℹ 320 more rows
#> # ℹ 91 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, TRT02P <fct>,
#> # TRT02A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> # BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> # AEWITHFL <fct>, RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>,
#> # TRT01SDTM <dttm>, TRT01EDTM <dttm>, TRT02SDTM <dttm>, TRT02EDTM <dttm>, …