Hy's Law Analysis Dataset (ADHY) — radhy • random.cdisc.data

Function for generating a random Hy's Law Analysis Dataset for a given Subject-Level Analysis Dataset.

Usage

radhy(
  adsl,
  param = c("TBILI <= 2 times ULN and ALT value category",
    "TBILI > 2 times ULN and AST value category",
    "TBILI > 2 times ULN and ALT value category",
    "TBILI <= 2 times ULN and AST value category",
    "TBILI > 2 times ULN and ALKPH <= 2 times ULN and ALT value category",
    "TBILI > 2 times ULN and ALKPH <= 2 times ULN and AST value category",
    "TBILI > 2 times ULN and ALKPH <= 5 times ULN and ALT value category",
    "TBILI > 2 times ULN and ALKPH <= 5 times ULN and AST value category",
    "TBILI <= 2 times ULN and two consecutive elevations of ALT in relation to ULN", 
   
     "TBILI > 2 times ULN and two consecutive elevations of AST in relation to ULN",
    "TBILI <= 2 times ULN and two consecutive elevations of AST in relation to ULN",
    "TBILI > 2 times ULN and two consecutive elevations of ALT in relation to ULN",
    "TBILI > 2 times ULN and two consecutive elevations of ALT in relation to Baseline",
    "TBILI <= 2 times ULN and two consecutive elevations of ALT in relation to Baseline",
    "TBILI > 2 times ULN and two consecutive elevations of AST in relation to Baseline",
    
    
    "TBILI <= 2 times ULN and two consecutive elevations of AST in relation to Baseline",
    "ALT > 3 times ULN by Period", "AST > 3 times ULN by Period",
    "ALT or AST > 3 times ULN by Period", "ALT > 3 times Baseline by Period",
    "AST > 3 times Baseline by Period", "ALT or AST > 3 times Baseline by Period"),
  paramcd = c("BLAL", "BGAS", "BGAL", "BLAS", "BA2AL", "BA2AS", "BA5AL", "BA5AS",
    "BL2AL2CU", "BG2AS2CU", "BL2AS2CU", "BG2AL2CU", "BG2AL2CB", "BL2AL2CB", "BG2AS2CB",
    "BL2AS2CB", "ALTPULN", "ASTPULN", "ALTASTPU", "ALTPBASE", "ASTPBASE", "ALTASTPB"),
  seed = NULL,
  cached = FALSE
)

Arguments

adsl: (data.frame)
Subject-Level Analysis Dataset (ADSL).
param: (character vector)
Parameter values.
paramcd: (character vector)
Parameter code values.
seed: (numeric)
Seed to use for reproducible random number generation.
cached: boolean whether the cached ADHY data cadhy should be returned or new data should be generated. If set to TRUE then the other arguments to radhy will be ignored.

Value

data.frame

Details

One record per subject per parameter per analysis visit per analysis date.

Keys: STUDYID, USUBJID, PARAMCD, AVISITN, ADTM, SRCSEQ

Author

wojciakw

Examples

library(random.cdisc.data)
adsl <- radsl(N = 10, seed = 1, study_duration = 2)

adhy <- radhy(adsl, seed = 2)
adhy
#> # A tibble: 500 × 71
#>    STUDYID USUBJID    SUBJID SITEID   AGE AGEU  SEX   RACE  ETHNIC COUNTRY DTHFL
#>    <chr>   <chr>      <chr>  <chr>  <int> <fct> <fct> <fct> <fct>  <fct>   <fct>
#>  1 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  2 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  3 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  4 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  5 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  6 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  7 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  8 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  9 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#> 10 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#> # ℹ 490 more rows
#> # ℹ 60 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> #   ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, TRT02P <fct>,
#> #   TRT02A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> #   BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> #   AEWITHFL <fct>, RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>,
#> #   TRT01SDTM <dttm>, TRT01EDTM <dttm>, TRT02SDTM <dttm>, TRT02EDTM <dttm>, …