Skip to contents

Exposure Analysis Dataset (ADEX)

radex.Rd

[Stable]

Function for generating random Exposure Analysis Dataset for a given Subject-Level Analysis Dataset.

Usage

radex(
  adsl,
  param = c("Dose administered during constant dosing interval",
    "Number of doses administered during constant dosing interval",
    "Total dose administered", "Total number of doses administered"),
  paramcd = c("DOSE", "NDOSE", "TDOSE", "TNDOSE"),
  paramu = c("mg", " ", "mg", " "),
  parcat1 = c("INDIVIDUAL", "OVERALL"),
  parcat2 = c("Drug A", "Drug B"),
  visit_format = "WEEK",
  n_assessments = 5L,
  n_days = 5L,
  max_n_exs = 6L,
  lookup = NULL,
  seed = NULL,
  na_percentage = 0,
  na_vars = list(AVAL = c(NA, 0.1), AVALU = c(NA), 0.1),
  cached = FALSE
)

Arguments

adsl

(data.frame)
Subject-Level Analysis Dataset (ADSL).

param

(character vector)
Parameter values.

paramcd

(character vector)
Parameter code values.

paramu

(character vector)
Parameter unit values.

parcat1

(character vector)
Dose amount categories. Defaults to "Individual" and "Overall".

parcat2

(character vector)
Types of drug received. Defaults to "Drug A" and "Drug B".

visit_format

(character)
Type of visit. Options are "WEEK" and "CYCLE".

n_assessments

(integer)
Number of weeks or cycles.

n_days

(integer)
Number of days in each cycle (only used if visit_format is "CYCLE").

max_n_exs

(integer)
Maximum number of exposures per patient. Defaults to 6.

lookup

(data.frame)
Additional parameters.

seed

(numeric)
Seed to use for reproducible random number generation.

na_percentage

(proportion)
Default percentage of values to be replaced by NA.

na_vars

(list)
A named list where the name of each element is a column name of ds. Each element of this list should be a numeric vector with two elements:

  • seed (numeric)
    The seed to be used for this element - can be NA.

  • percentage (proportion)
    Percentage of elements to be replaced with NA. If NA, na_percentage is used as a default.

cached

boolean whether the cached ADEX data cadex should be returned or new data should be generated. If set to TRUE then the other arguments to radex will be ignored.

Value

data.frame

Details

One record per each record in the corresponding SDTM domain.

Keys: STUDYID, USUBJID, EXSEQ, PARAMCD, PARCAT1, ASTDTM, AENDTM, ASTDY, AENDY, AVISITN, EXDOSFRQ, EXROUTE, VISIT, VISITDY, EXSTDTC, EXENDTC, EXSTDY, EXENDY

Examples

library(random.cdisc.data)
adsl <- radsl(N = 10, study_duration = 2, seed = 1)

adex <- radex(adsl, seed = 2)
adex
#> # A tibble: 160 × 79
#>    STUDYID USUBJID    SUBJID SITEID   AGE AGEU  SEX   RACE  ETHNIC COUNTRY DTHFL
#>    <chr>   <chr>      <chr>  <chr>  <int> <fct> <fct> <fct> <fct>  <fct>   <fct>
#>  1 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  2 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  3 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  4 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  5 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  6 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  7 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  8 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#>  9 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#> 10 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… UNKNO… BRA     N    
#> # ℹ 150 more rows
#> # ℹ 68 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> #   ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, TRT02P <fct>,
#> #   TRT02A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> #   BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> #   AEWITHFL <fct>, RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>,
#> #   TRT01SDTM <dttm>, TRT01EDTM <dttm>, TRT02SDTM <dttm>, TRT02EDTM <dttm>, …