Exposure Analysis Dataset (ADEX)
radex.Rd
Function for generating random Exposure Analysis Dataset for a given Subject-Level Analysis Dataset.
Usage
radex(
adsl,
param = c("Dose administered during constant dosing interval",
"Number of doses administered during constant dosing interval",
"Total dose administered", "Total number of doses administered"),
paramcd = c("DOSE", "NDOSE", "TDOSE", "TNDOSE"),
paramu = c("mg", " ", "mg", " "),
parcat1 = c("INDIVIDUAL", "OVERALL"),
parcat2 = c("Drug A", "Drug B"),
visit_format = "WEEK",
n_assessments = 5L,
n_days = 5L,
max_n_exs = 6L,
lookup = NULL,
seed = NULL,
na_percentage = 0,
na_vars = list(AVAL = c(NA, 0.1), AVALU = c(NA), 0.1),
cached = FALSE
)
Arguments
- adsl
(
data.frame
)
Subject-Level Analysis Dataset (ADSL).- param
(
character vector
)
Parameter values.- paramcd
(
character vector
)
Parameter code values.- paramu
(
character vector
)
Parameter unit values.- parcat1
(
character vector
)
Dose amount categories. Defaults to "Individual" and "Overall".- parcat2
(
character vector
)
Types of drug received. Defaults to "Drug A" and "Drug B".- visit_format
(
character
)
Type of visit. Options are "WEEK" and "CYCLE".- n_assessments
(
integer
)
Number of weeks or cycles.- n_days
(
integer
)
Number of days in each cycle (only used ifvisit_format
is "CYCLE").- max_n_exs
(
integer
)
Maximum number of exposures per patient. Defaults to 6.- lookup
(
data.frame
)
Additional parameters.- seed
(
numeric
)
Seed to use for reproducible random number generation.- na_percentage
(
proportion
)
Default percentage of values to be replaced byNA
.- na_vars
(
list
)
A named list where the name of each element is a column name ofds
. Each element of this list should be a numeric vector with two elements:seed
(numeric
)
The seed to be used for this element - can beNA
.percentage
(proportion
)
Percentage of elements to be replaced withNA
. IfNA
,na_percentage
is used as a default.
- cached
boolean whether the cached ADEX data
cadex
should be returned or new data should be generated. If set toTRUE
then the other arguments toradex
will be ignored.
Details
One record per each record in the corresponding SDTM domain.
Keys: STUDYID
, USUBJID
, EXSEQ
, PARAMCD
, PARCAT1
, ASTDTM
, AENDTM
, ASTDY
, AENDY
,
AVISITN
, EXDOSFRQ
, EXROUTE
, VISIT
, VISITDY
, EXSTDTC
, EXENDTC
, EXSTDY
, EXENDY
Examples
library(random.cdisc.data)
adsl <- radsl(N = 10, study_duration = 2, seed = 1)
adex <- radex(adsl, seed = 2)
adex
#> # A tibble: 160 × 79
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 2 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 3 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 4 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 5 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 6 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 7 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 8 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 9 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> 10 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… UNKNO… BRA N
#> # ℹ 150 more rows
#> # ℹ 68 more variables: INVID <chr>, INVNAM <chr>, ARM <fct>, ARMCD <fct>,
#> # ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>, TRT01A <fct>, TRT02P <fct>,
#> # TRT02A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> # BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> # AEWITHFL <fct>, RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>,
#> # TRT01SDTM <dttm>, TRT01EDTM <dttm>, TRT02SDTM <dttm>, TRT02EDTM <dttm>, …