Vital Signs Analysis Dataset (ADVS)

Function for generating random dataset from Vital Signs Analysis Dataset for a given Subject-Level Analysis Dataset.

radvs(
  ADSL,
  param = c("Diastolic Blood Pressure", "Pulse Rate", "Respiratory Rate",
    "Systolic Blood Pressure", "Temperature", "Weight"),
  paramcd = c("DIABP", "PULSE", "RESP", "SYSBP", "TEMP", "WEIGHT"),
  paramu = c("Pa", "beats/min", "breaths/min", "Pa", "C", "Kg"),
  visit_format = "WEEK",
  n_assessments = 5L,
  n_days = 5L,
  seed = NULL,
  na_percentage = 0,
  na_vars = list(CHG2 = c(1235, 0.1), PCHG2 = c(1235, 0.1), CHG = c(1234, 0.1), PCHG =
    c(1234, 0.1), AVAL = c(123, 0.1), AVALU = c(123, 0.1)),
  cached = FALSE
)

Arguments

ADSL

Subject-Level Analysis Dataset (ADSL).

param

As character string. list of parameter values.

paramcd

As character string. list of parameter code values.

paramu

As character string. list of parameter unit values.

visit_format

Type of visit either "WEEK" or "CYCLE".

n_assessments

Number of weeks or cycles.

n_days

Number of days within cycle.

seed

Seed for random number generation.

na_percentage

(numeric) Default percentage of values to be replaced by NA

na_vars

(list) A named list where the name of each element is a column name of ds. Each element of this list should be a numeric vector with two elements

• seed The seed to be used for this element - can be left NA

• percentage How many element should be replaced. 0 is 0 % 1 is 100 %, can be left NA and default percentage is used. This will overwrite default percentage (percentage argument))

cached

boolean whether the cached ADVS data cadvs should be returned or new data should be generated. If set to TRUE then the other arguments to radvs will be ignored.

Value

data.frame

Details

One record per subject per parameter per analysis visit per analysis date.

Keys: STUDYID, USUBJID, PARAMCD, BASETYPE, AVISITN, ATPTN, DTYPE, ADTM, VSSEQ, ASPID.

Author

npaszty

Examples

library(random.cdisc.data)
ADSL <- radsl(N = 10, seed = 1, study_duration = 2)
radvs(ADSL, visit_format = "WEEK", n_assessments = 7L, seed = 2)
#> # A tibble: 540 × 76
#>    STUDYID USUBJID    SUBJID SITEID   AGE AGEU  SEX   RACE  ETHNIC COUNTRY DTHFL
#>    <chr>   <chr>      <chr>  <chr>  <int> <fct> <fct> <fct> <fct>  <fct>   <fct>
#>  1 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  2 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  3 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  4 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  5 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  6 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  7 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  8 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  9 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#> 10 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#> # … with 530 more rows, and 65 more variables: INVID <chr>, INVNAM <chr>,
#> #   ARM <fct>, ARMCD <fct>, ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>,
#> #   TRT01A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> #   BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> #   RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>,
#> #   EOSDT <date>, EOSDY <int>, DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>,
#> #   DTHCAT <fct>, LDDTHELD <int>, LDDTHGR1 <fct>, LSTALVDT <date>, …
radvs(ADSL, visit_format = "CYCLE", n_assessments = 3L, seed = 2)
#> # A tibble: 960 × 76
#>    STUDYID USUBJID    SUBJID SITEID   AGE AGEU  SEX   RACE  ETHNIC COUNTRY DTHFL
#>    <chr>   <chr>      <chr>  <chr>  <int> <fct> <fct> <fct> <fct>  <fct>   <fct>
#>  1 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  2 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  3 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  4 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  5 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  6 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  7 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  8 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#>  9 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#> 10 AB12345 AB12345-B… id-9   BRA-1     35 YEARS F     BLAC… NOT H… BRA     N    
#> # … with 950 more rows, and 65 more variables: INVID <chr>, INVNAM <chr>,
#> #   ARM <fct>, ARMCD <fct>, ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>,
#> #   TRT01A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> #   BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> #   RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>,
#> #   EOSDT <date>, EOSDY <int>, DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>,
#> #   DTHCAT <fct>, LDDTHELD <int>, LDDTHGR1 <fct>, LSTALVDT <date>, …