radhy.RdFunction for generating random dataset from Hys Law Analysis Dataset for a given Subject-Level Analysis Dataset.
radhy(
ADSL,
param = c("TBILI <= 2 times ULN and ALT value category",
"TBILI > 2 times ULN and AST value category",
"TBILI > 2 times ULN and ALT value category",
"TBILI <= 2 times ULN and AST value category",
"TBILI > 2 times ULN and ALKPH <= 2 times ULN and ALT value category",
"TBILI > 2 times ULN and ALKPH <= 2 times ULN and AST value category",
"TBILI > 2 times ULN and ALKPH <= 5 times ULN and ALT value category",
"TBILI > 2 times ULN and ALKPH <= 5 times ULN and AST value category",
"TBILI <= 2 times ULN and two consecutive elevations of ALT in relation to ULN",
"TBILI > 2 times ULN and two consecutive elevations of AST in relation to ULN",
"TBILI <= 2 times ULN and two consecutive elevations of AST in relation to ULN",
"TBILI > 2 times ULN and two consecutive elevations of ALT in relation to ULN",
"TBILI > 2 times ULN and two consecutive elevations of ALT in relation to Baseline",
"TBILI <= 2 times ULN and two consecutive elevations of ALT in relation to Baseline",
"TBILI > 2 times ULN and two consecutive elevations of AST in relation to Baseline",
"TBILI <= 2 times ULN and two consecutive elevations of AST in relation to Baseline",
"ALT > 3 times ULN by Period", "AST > 3 times ULN by Period",
"ALT or AST > 3 times ULN by Period", "ALT > 3 times Baseline by Period",
"AST > 3 times Baseline by Period", "ALT or AST > 3 times Baseline by Period"),
paramcd = c("BLAL", "BGAS", "BGAL", "BLAS", "BA2AL", "BA2AS", "BA5AL", "BA5AS",
"BL2AL2CU", "BG2AS2CU", "BL2AS2CU", "BG2AL2CU", "BG2AL2CB", "BL2AL2CB", "BG2AS2CB",
"BL2AS2CB", "ALTPULN", "ASTPULN", "ALTASTPU", "ALTPBASE", "ASTPBASE", "ALTASTPB"),
seed = NULL,
cached = FALSE
)Subject-Level Analysis Dataset (ADSL).
As character string. list of parameter values.
As character string. list of parameter code values.
Seed for random number generation.
boolean whether the cached ADHY data cadhy should be returned or new data
should be generated. If set to TRUE then the other arguments to radhy will be ignored.
data.frame
One record per subject per parameter per analysis visit per analysis date.
Keys: STUDYID, USUBJID, PARAMCD, AVISITN, ADTM, SRCSEQ.
library(random.cdisc.data)
ADSL <- radsl(N = 10, seed = 1, study_duration = 2)
radhy(ADSL, seed = 2)
#> # A tibble: 500 × 60
#> STUDYID USUBJID SUBJID SITEID AGE AGEU SEX RACE ETHNIC COUNTRY DTHFL
#> <chr> <chr> <chr> <chr> <int> <fct> <fct> <fct> <fct> <fct> <fct>
#> 1 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 2 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 3 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 4 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 5 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 6 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 7 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 8 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 9 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> 10 AB12345 AB12345-B… id-9 BRA-1 35 YEARS F BLAC… NOT H… BRA N
#> # … with 490 more rows, and 49 more variables: INVID <chr>, INVNAM <chr>,
#> # ARM <fct>, ARMCD <fct>, ACTARM <fct>, ACTARMCD <fct>, TRT01P <fct>,
#> # TRT01A <fct>, REGION1 <fct>, STRATA1 <fct>, STRATA2 <fct>, BMRKR1 <dbl>,
#> # BMRKR2 <fct>, ITTFL <fct>, SAFFL <fct>, BMEASIFL <fct>, BEP01FL <fct>,
#> # RANDDT <date>, TRTSDTM <dttm>, TRTEDTM <dttm>, EOSSTT <fct>, EOTSTT <fct>,
#> # EOSDT <date>, EOSDY <int>, DCSREAS <fct>, DTHDT <date>, DTHCAUS <fct>,
#> # DTHCAT <fct>, LDDTHELD <int>, LDDTHGR1 <fct>, LSTALVDT <date>, …